ZCCHC6 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1239 Sequence: atgggagata cagcaaaacc ttatttcgtg aagcgcacta aagaccgggg gactatggat gatgatgact tcagaagggg tcacccccaa caagattatt taataataga tgaccatgct aaaggccatg gcagtaaaat ggaaaagggc cttcaaaaaa agaagataac accagggaac tatgggaata cccccagaaa aggaccatgt gctgtttcca gcaatccata tgcatttaaa aacccaatct acagtcaacc cgcttggatg aatgacagcc acaaagatca gagtaagaga tggctgtctg atgaacatac tggtaattca gacaactgga gagaattcaa acctggacct agaattcctg ttataaaccg acaaagaaaa gactcctttc aagaaaatga agatggttat aggtggcaag acacaagagg ctgcagaact gtaagacgac tgtttcataa agacctaaca agcctagaaa ccacgtcaga aatggaagca ggaagtcctg aaaacaagaa gcagaggtcc agacctagga agccacggaa gactagaaat gaggaaaatg agcaggatgg agacttggaa ggccctgtga tcgatgagtc tgtactttca acgaaggagc tgctaggctt acagcaggct gaggagagac tgaagagaga ctgcattgac aggctaaaaa ggcgaccacg aaactaccct acagcaaagt acacctgcag actctgtgat gttttaattg aatccattgc atttgcccat aagcatatca aggaaaagag gcacaagaaa aacattaagg agaagcaaga ggaagagttg ctcactacgt tacccccacc aacaccctcc cagataaatg cagttggcat tgccattgac aaagtggtac aggaatttgg cttacacaat gagaacttgg aacagaggct ggaaattaaa cgtatcatgg aaaatgtgtt ccaacacaag ttaccagatt gttccctaag attatatggg tcatcctgta gcagattggg tttcaaaaat tcggatgtaa acattgacat ccagtttcca gccattatgt ctcagccaga tgtcctctta cttgttcaag aatgtttaaa gaacagtgac tcctttattg atgttgatgc agacttccat gctagggtgc cagtggtggt gtgcagagaa aagcaaaggt ctcatttctt taaactgttt Protein function: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:19703396, PubMed:22898984, PubMed:18172165, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). [The UniProt Consortium]