YTHDF3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1758 Sequence: atgtcagcca ctagcgtgga tcagagacct aaagggcaag gaaataaagt ttcagtacaa aacggttcga ttcatcaaaa agatgctgta aatgatgatg attttgagcc atacttaagt agccagacaa atcagagtaa cagctatcca ccaatgtcag atccatacat gcctagttac tatgctccat ccattggatt tccatattct cttggggaag cagcgtggtc cacagctgga gaccagccta tgccatatct gacaacctat ggacaaatga gtaatggaga acatcactat ataccagatg gtgtatttag tcaacctggg gcattaggaa atacccctcc atttcttggt caacatggat ttaacttttt tcctggtaat gctgatttct ctacatgggg gacaagtgga tctcagggac aatcaacaca aagttctgct tatagtagca gttatggcta tccacctagt tctcttggga gagctattac tgatggacag gctggatttg gcaatgatac tttgagtaag gtgcctggca ttagcagtat tgagcaaggc atgactggac tgaaaattgg tggtgacctg acagctgcag tgacaaaaac tgtaggtaca gctttgagca gcagtggtat gactagcatt gcaaccaata gtgtgccccc agttagcagt gcagcaccta aaccaacctc ctgggctgcc attgccagaa agcctgccaa acctcaaccg aaacttaaac ccaagggcaa tgtgggaatt gggggttctg ctgtaccacc acctcctata aaacacaaca tgaatattgg aacttgggat gaaaaagggt cagtggtaaa ggctccacca acccaaccag ttctgcctcc tcaaactata atccagcagc ctcagccatt aattcaacca ccaccattgg tgcaaagcca actgcctcaa cagcagcctc aaccaccaca accacagcag caacaaggac ctcagccaca ggcccagcct caccaagtgc agcctcaaca gcagcagctg cagaatcgct gggtagctcc tcgtaacagg ggagcaggct tcaaccagaa caatggagcg ggcagtgaaa actttggttt aggtgttgta cctgtcagtg cttcaccttc tagtgtagaa gtgcatcccg tgctggaaaa gctaaaggcc ataaacaact ataatcccaa agactttgat tggaatctga agaatggacg tgtgtttata attaaaagct actctgagga tgacatacat cgttccatta aatactctat ctggtgtagt actgagcatg gtaataagcg tttggatgca gcttaccgtt ccctgaatgg gaaaggccca ctctatttac tcttcagtgt gaatggcagt ggacattttt gtggagtggc tgaaatgaag tctgttgtgg actataatgc gtatgctggt gtctggtctc aggataagtg gaagggcaaa tttgaagtta aatggatctt tgtcaaagat gttcccaata accaattacg gcatattcgc ttagaaaata atgacaacaa accggttacc aattcaaggg acactcaaga ggtaccccta gaaaaagcta agcaagtgct taaaataatt gctactttca agcataccac ctcaatcttt gatgactttg cacattatga aaagcgtcaa gaagaggagg aagccatgcg tagggagaga aatagaaaca Protein function: Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs and promotes RNA translation efficiency (PubMed:28106072, PubMed:28106076, PubMed:28281539). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28106076, PubMed:28281539). Shares m6A-containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (PubMed:28106072, PubMed:28106076). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRNAs and interacting with 40S and 60S ribosome subunits (PubMed:28106072, PubMed:28106076). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs and promoting their translation. Binds to FOXO3 mRNAs independently of METTL3- mediated m6A modification. Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A- containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs) and promotes their translation (PubMed:28281539). circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). [The UniProt Consortium]