WIPI1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1341 Sequence: atggaggccg aggccgcgga cgctcccccg ggcggggttg agtcggcgct cagctgcttc tctttcaacc aggactgcac atccctagca attggaacta aagccgggta taagctgttt tctctgagtt ctgtggagca gctggatcaa gtccacggaa gcaatgaaat cccggacgtc tacatcgtgg agcgcctctt ctccagcagc ctggtggtgg tagtcagtca cacaaaacca cggcagatga acgtgtatca cttcaagaaa ggcacagaga tctgtaatta cagctactcc agcaacatct tgtccataag gctgaaccgg caaaggctgc tggtttgcct agaagagtcc atttatattc acaacattaa agacatgaag ctgttgaaga ccctcctgga tattcctgca aacccaacag gtctatgtgc tctctctatc aaccattcca attcttacct ggcctatcct ggaagcctga cttcagggga gattgtgctt tatgatggaa actccctgaa aacagtctgc actattgctg cccatgaggg aacactagct gccatcacct tcaatgcctc aggctccaaa ctagcaagtg cgtctgaaaa aggcacagtc atccgggtgt tctctgtccc tgatgggcaa aagctctatg agttccggag agggatgaaa aggtatgtga caatcagctc tctagtgttc agtatggatt cacaattcct ctgcgcctcc agtaacaccg agacggtaca catcttcaag ctggaacagg tcaccaacag tcgaccagaa gagccttcga cctggagtgg ctacatggga aagatgttta tggctgctac caactacctc cctacccagg tgtcagacat gatgcatcag gacagggctt ttgccactgc acgcttgaac ttctccggac agaggaacat ctgtaccctc tcaacgatcc agaagttgcc acggctgcta gttgcgtcat ccagtggaca cctttatatg tacaatttgg atcctcagga tggaggagag tgtgtcttaa tcaaaaccca cagcttgctt ggctcaggaa caacagaaga gaataaagaa aatgacctca gaccttcctt acctcagtct tatgcagcga ccgtagccag accaagtgca tcttcagcct ccacggtgcc aggttattct gaggacggcg gggcgctgcg aggagaagtt attcctgaac atgagtttgc gacgggacca gtgtgtcttg atgatgagaa tgagtttcct cctataatct tgtgccgtgg aaatcagaag ggcaaaacga agcagtcatg Protein function: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Plays an important role in starvation- and calcium- mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066). There, it assists WIPI2 in the recruitment of ATG12- ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6- phosphate receptor (MPR) recycling pathway. [The UniProt Consortium]