WDYHV1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 618 Sequence: atggaaggta atggccccgc tgctgtccac taccagccgg ccagcccccc gcgggacgcc tgcgtctaca gcagctgcta ctgtgaagaa aatgtttgga agctctgtga atacatcaaa aaccatgacc agtatccttt agaagaatgt tatgctgtct tcatatctaa tgagaggaag atgataccta tctggaaaca acaggcgaga cctggagatg gacctgtgat ctgggattac catgttgttt tgcttcatgt ttcaagtgga ggacagagct tcatttatga tctcgatact gtcttgccat ttccctgcct ctttgacact tatgtagaag atgccattaa gtctgatgat gacattcacc cacagtttag gaggaaattt agagtgatct gtgcagattc atatttgaag aactttgctt ctgaccgatc tcacatgaaa gactccagtg ggaattggag agagcctccg ccgccatatc cctgcattga gactggagat tccaaaatga acctgaacga tttcatcagt atggatccca aggtaggatg gggcgccgtc tacacactat ccgaatttac acatcggttt ggcagtaaaa Protein function: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. [The UniProt Consortium]