WDR91 (Vector pENTR223.1, Accession No. BC017246)

Length: 2244 Sequence: atggcggagg ccgtggagcg cactgacgag ctggtccggg agtacctgct cttccgcggg ttcacgcaca cactgcggca gctggacgcc gagatcaagg cggacaagga gaaggggttc cgggtggata agattgtgga ccagctgcag cagttaatgc aggtgtatga cttggctgcc cttcgggatt attggagcta cttggagcgt cggctcttca gccgcttgga ggatatatac agacccacaa tccacaagct gaaaaccagc ctgtttcgat tttatcttgt ctacacaatc cagacaaaca gaaatgacaa ggctcaggag ttctttgcaa agcaggccac ggaactccag aaccaggctg agtggaagga ttggtttgtc ctgcccttcc tgccatcccc ggacaccaac cccacctttg ctacctactt ttctcgacag tgggctgaca ccttcattgt gtccctgcac aacttcctga gcgtcctgtt tcagtgcatg ccagtccctg tgatcctgaa ctttgatgcg gagtgtcaga ggactaacca ggttcaagaa gaaaatgaag ttctgcgtca gaagcttttt gcattgcaag ctgaaatcca ccgactgaag aaagaggagc aacagccaga agaggaagag gccttggtcc aacacaaatt gcctccttat gtctccaaca tggaccgcct gggggactcg gaacttgcca tggtgtgcag ccaaaggaat gcctccctct cccagtcacc tcgtgtgggc ttcctgtcct cgctgctgcc tcagagtaag aagagcccct caaggttgtc gcctgctcag ggccctcctc aacctcagag ctcggccaag aaagagtcct tcggtggtca gggcaccaag ggaaaggacc cgacgtccgg agccaaggat gggaagagcc tcctcagcgg gctggccact ggggagtccg gttggtcaca gcaccggcag cggcgcctgc aggaccatgg caaggagagg aaggagcttt tctccacaac cacttcccag tgtgcagaga agaaaccaga agccagtggc ccagaggctg agccctgccc agagctccac acggagccag tggagccact gactcgggca tcctcggcag gccctgaggg tggaggagtc cgccccgagc agccctttat tgtgctggga caggaggagt acggggaaca ccactcatcc atcatgcact gcagagtgga ctgctctggg aggagagtcg ccagcttaga cgtagatggg gtcatcaaag tgtggtcctt caaccccatc atgcagacca aagcatcctc catttccaaa tcaccgctgc tgtctttgga atgggccacc aaacgggaca gactgctctt gctgggcagt ggtgtgggaa cagtgcgtct ctatgacacg gaagccaaga agaatctctg tgaaatcaat atcaacgaca acatgcccag aatcctgtct cttgcgtgca gccccaacgg ggcctctttc gtctgttcgg cagcagctcc gagcctcact tcccaggtgg acttctcagc accagacatc ggcagcaagg gcatgaacca ggttcctggc aggctgctgc tgtgggacac gaaaaccatg aagcagcagc tccagttctc cctggatcca gaacccattg ctatcaactg tacagccttc aatcacaacg ggaacctgct ggtcacaggg gcagctgatg gcgtcatccg gctgtttgac atgcagcagc atgagtgcgc gatgagctgg agggcccact acggggaggt ctactctgtg gagttcagct atgatgagaa caccgtgtac agcatcggcg aggacgggaa gttcatccag tggaacatcc acaagagtgg cctcaaggta tccgagtaca gcctcccctc agatgccacg ggcccctttg tgctgtctgg atacagcggc tacaagcagg ttcaagtccc caggggccga ctcttcgctt ttgactcgga gggaaattac atgctgacat gttctgccac aggcggcgtc atctacaagc tgggtggcga tgagaaggtt ctggagagct gcttgagcct aggtggccac cgagcccctg tggtcaccgt ggactggagc actgccatgg actgtgggac ctgcctcacc gcctccatgg atggcaagat caagctgacc accctcctgg cccataaagc Protein function: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis. [The UniProt Consortium]