WDR59 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1716 Sequence: atggcggcgc gatggagcag cgaaaacgtg gttgtagagt tccgtgactc ccaggcaact gcgatgtctg tggactgtct tgggcagcat gcagtgcttt ctggccgcag attcttatac atcgtcaatc tagatgcccc tttcgaaggt caccgaaaga tctctcgcca gagcaaatgg gacattggag ctgtgcagtg gaatcctcat gacagctttg cacactattt tgcggcttcg agtaaccaac gagtagacct ttacaagtgg aaagacggca gtggggaagt tggcacaacc ttacaaggcc acactcgtgt catcagcgac ttggactggg cggtgtttga gcctgacctc ctggttacca gctctgtgga cacctacatc tacatttggg atatcaaaga cacaaggaaa cctactgttg cactgtctgc tgttgcgggt gcctcccagg tcaaatggaa taaaaaaaat gctaactgcc ttgccaccag ccatgacggc gatgtgcgga tatgggataa gaggaaaccc agtacagcag tggaatatct agccgcccac ctctccaaaa tccatggcct ggactggcac ccagacagcg agcacattct tgctacctcc agtcaagaca attctgtgaa gttctgggat taccgccagc ctcggaaata cctcaatatt cttccttgcc aggtgcctgt ctggaaggcc agatacacac ctttcagcaa tggattggtg actgtgatgg ttccccagct gcggagggaa aacagccttc tcctgtggaa tgtctttgac ttgaacaccc cagtccacac cttcgtgggg catgatgatg tggtcctgga gttccagtgg aggaagcaga aggaagggtc caaggactat caactggtga cgtggtcccg ggatcagacc ttgagaatgt ggcgggtgga ttcccagatg cagaggcttt gtgcaaatga catattagat ggtgttgatg agttcattga gagtatttcc cttctgccgg aacctgagaa gaccctgcac actgaagata cagatcacca gcacactgca agccatgggg aggaagaagc cctaaaagaa gatcccccta gaaatctcct ggaagagagg aaatcagatc aactggggct gcctcagacc ttgcagcagg aattctccct gatcaatgtg caaatccgga atgtcaatgt ggagatggat gcggcagaca ggagctgcac agtgtctgtg cactgcagca accatcgtgt caagatgctg gtgaagttcc ctgcacagta cccaaacaac gccgcccctt ccttccagtt tattaacccc acaaccatca catccaccat gaaagctaag ctgctgaaga tcctgaagga cacagccctg cagaaagtga agcgtggcca gagctgcctg gagccctgcc tgcgccagct cgtctcctgc cttgagtcct ttgtgaacca ggaagacagc gcttccagca acccgtttgc actccccaac tctgtcactc cccccttacc gacgtttgcg cgggtgacca cggcttacgg gtcgtaccag gacgccaaca ttccctttcc taggacttct ggggccaggt tctgcggagc aggttacctg gtatatttca caaggcccat gacaatgcat cgggcggtgt ctcccacaga gcctactccg Protein function: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [The UniProt Consortium]