WDR4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 801 Sequence: atgctgttag atgtggctgt gagtcctgat gaccgcttca tcctcactgc cgaccgggac gagaagatcc gagtcagctg ggccgcggcg ccccatagca tcgagtcctt ctgcttgggg cacacagagt ttgtgagccg tatctccgtg gtgccaactc agcccgggct gcttctgtcc tcctctgggg acggcaccct gaggctctgg gagtacagga gcggccgcca gctgcactgc tgtcacctgg ccagtctgca ggagctggtg gacccccagg ccccccagaa gtttgccgcg tccaggattg cattctggtg ccaggagaac tgcgtggcgc tcctgtgcga cggcacttct gtggtctaca tcttccagct ggacgcccgc agacagcagt tggtgtacag gcagcagctg gcgttccagc accaagtgtg ggacgtggct ttcgaggaga cccaggggct gtgggtgctc caggactgcc aggaagcccc cctggtgctc tacaggcctg tgggcgacca gtggcagtct gttcctgaga gcaccgtgtt aaagaaagtc tctggtgttc ttcgtgggaa ctgggccatg ctggaaggct ctgccggcgc agacgccagc ttcagcagtc tctacaaggc cacgttcgac aacgtgacct cctacctgaa gaagaaagag gagagactgc agcagcagct agagaagaag cagcggcgcc ggagtccccc gcctgggccc gacgggcatg ccaagaagat gagaccgggg gaggcgacgc taagttgctg Protein function: Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (PubMed:12403464). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069). [The UniProt Consortium]