WDR24 (Vector pUC, Accession No. BC008025)

Length: 2373 Sequence: atggagaaga tgtcccgtgt gaccacagcc ctgggtggca gcgtgctgac aggccgcacc atgcactgcc acctggatgc tcccgccaat gccatcagtg tgtgccgcga cgcagcccag gtggtcgtgg caggccgtag catcttcaag atctatgcca tcgaggagga acagttcgtg gaaaagctga acctgcgtgt ggggcgcaag ccttcgctta acctgagctg tgctgacgtg gtctggcacc agatggatga gaacctgctg gccacagcag ccaccaatgg cgtggtggtc acgtggaacc tgggccggcc atcccgcaac aagcaggacc agctgttcac agaacacaag cgcacggtaa acaaagtctg cttccacccc accgaagccc acgtgctgct cagtggctcc caggatggct tcatgaagtg ctttgacctc cgcagaaagg actctgtcag caccttctcg ggccagtcgg agagcgtgcg ggacgtgcag ttcagtatcc gggactactt caccttcgcc tccacctttg agaacggcaa tgtgcagctc tgggacatcc ggcgtcccga ccggtgcgag aggatgttca cagcccacaa cggacccgtc ttctgctgcg actggcaccc cgaggacagg ggctggttgg ccactggagg gcgcgacaag atggtgaagg tctgggacat gaccacgcac cgtgccaagg agatgcactg tgtgcagacc atcgcctcgg tggcccgtgt gaagtggcgg ccagagtgcc gccaccacct ggccacatgc tccatgatgg tggaccacaa catctatgtt tgggacgtgc gccggccctt cgtgccagct gccatgtttg aggaacaccg agacgtcacc acgggaattg cctggcgcca cccccacgac ccctccttcc tgctgtctgg ctccaaggac agctcgctgt gccagcacct gttccgcgac gccagccagc ccgtcgagcg cgccaaccct gagggcctct gctacggcct cttcggggac ctggccttcg ccgccaagga gagcctcgtg gctgccgagt cggggcgcaa gccctacact ggcgaccggc gccaccccat cttctttaag cgcaagctgg accctgccga gcccttcgca ggcctcgcct ccagtgccct cagtgtcttt gagacggagc caggtggcgg cggcatgcgc tggtttgtgg acacagctga gcgttatgcg ctggctggcc ggccactggc cgagctctgt gaccacaacg caaaggtggc tcgagagctt ggccgcaacc aggtggcgca aacgtggacc atgctgcgga tcatctactg cagccctggc ctagtgccca ctgcaaacct caaccacagt gtgggcaagg gtggctcctg tggcctcccg ctcatgaaca gtttcaacct gaaggatatg gccccagggt tgggcagtga gacgcggctg gaccgcagca aaggagatgc acggagcgac acagttctgc tcgactcctc ggccacactc atcaccaatg aggataacga ggaaaccgag ggcagcgacg tacctgccga ctacctgctg ggtgacgtgg aaggtgagga ggacgagctg tacctgctgg atccggaaca cgcgcacccc gaggaccctg agtgcgtgct gccgcaggag gcctttccgc tgcgccacga gatcgtggac acgcctcccg ggcccgagca cctgcaggac aaggccgact ccccgcacgt gagcggcagc gaggcggatg tggcctccct ggcccccgtg gactcctcct tctcgctcct gtctgtctca cacgcgctct acgacagccg cctgccgccc gacttcttcg gcgtgctggt gcgcgacatg ctgcacttct acgctgagca gggcgacgtg cagatggctg tgtctgtgct catcgtcctg ggtgaacggg tgcgcaagga catcgacgag cagacccagg agcactggta cacttcctac atcgacctgc tgcagcgctt ccgcctctgg aacgtgtcca acgaggtggt caagctgagc accagccgcg ccgtcagctg cctcaaccag gcctccacca ccctgcacgt caactgcagc cactgcaagc ggcccatgag cagccggggc tgggtctgcg acaggtgcca ccgctgcgcc agcatgtgtg ccgtctgcca ccacgtagtc aagggtctct tcgtgtggtg ccagggctgc agccacggcg gccacctgca gcacatcatg aagtggctgg aaggcagctc ccactgtccc gcaggctgcg gccacctctg cgagtactcc Protein function: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823). [The UniProt Consortium]