VSX2 (Vector pUC, Accession No. BC128153)

Length: 1086 Sequence: ATGACGGGGA AAGCAGGGGA AGCGCTGAGC AAGCCCAAAT CCGAGACAGT GGCCAAGAGT ACCTCGGGGG GCGCCCCGGC CAGGTGCACT GGGTTCGGCA TCCAGGAGAT CCTGGGCTTG AACAAGGAGC CCCCGAGCTC CCACCCGCGG GCAGCGCTCG ACGGCCTGGC CCCCGGGCAC TTGCTGGCGG CGCGCTCAGT GCTCAGCCCC GCGGGGGTGG GCGGCATGGG GCTTCTGGGG CCCGGGGGGC TCCCTGGCTT CTACACGCAG CCCACCTTCC TGGAAGTGCT GTCCGACCCG CAGAGCGTCC ACTTGCAGCC ATTGGGCAGA GCATCGGGGC CGCTGGACAC CAGCCAGACG GCCAGCTCGG ATTCTGAAGA TGTTTCCTCC AGCGATCGAA AAATGTCCAA ATCTGCTTTA AACCAGACCA AGAAACGGAA GAAGCGGCGA CACAGGACAA TCTTTACCTC TTACCAGCTA GAGGAGCTGG AGAAGGCATT CAACGAAGCC CACTACCCAG ACGTCTATGC CCGGGAGATG CTGGCCATGA AAACGGAGCT GCCGGAAGAC AGGATACAGG TCTGGTTCCA GAACCGTCGA GCCAAGTGGA GGAAGCGGGA GAAGTGCTGG GGCCGGAGCA GTGTCATGGC GGAGTATGGG CTCTACGGGG CCATGGTGCG GCACTCCATC CCCCTGCCCG AGTCCATCCT CAAGTCAGCC AAGGATGGCA TCATGGACTC CTGTGCCCCG TGGCTACTGG GGATGCACAA AAAGTCGCTG GAGGCAGCAG CCGAGTCGGG GAGGAAGCCC GAGGGGGAAC GCCAGGCCCT GCCCAAGCTC GACAAGATGG AGCAGGACGA GCGGGGCCCC GACGCTCAGG CGGCCATCTC CCAGGAGGAA CTGAGGGAGA ACAGCATTGC GGTGCTCCGG GCCAAAGCTC AGGAGCACAG CACCAAAGTG CTGGGGACTG TGTCTGGGCC GGACAGCCTG GCCCGGAGTA CCGAGAAGCC AGAGGAGGAG GAGGCCATGG ATGAAGACAG GCCGGCGGAG AGGCTCAGTC CACCGCAGCT GGAGGACATG Protein function: Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters (PubMed:27301076). Plays a significant role in the specification and morphogenesis of the sensory retina. Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 (PubMed:17919464, PubMed:27477290). Acts as a positive transcriptional regulator of NXNL1, regulation is significantly increased in synergy with VSX1. Acts as a negative transcriptional regulator of MITF. Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (PubMed:16236706, PubMed:27477290). Binds to the photoreceptor conserved element-1 (PCE- 1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor. Plays a significant role in the specification and morphogenesis of the sensory retina. Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells. Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation. May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (PubMed:27301076). [The UniProt Consortium]