VPS33B (Vector pUC, Accession No. BC016445)

Length: 1854 Sequence: atggcttttc cccatcggcc ggacgcccct gagctgcctg acttctccat gctgaagagg ctggctcgag accagctcat ctatctgctg gagcagcttc ctggaaaaaa ggatttattc attgaggcag atctcatgag ccctttggat cgaattgcca atgtctccat cctgaagcaa cacgaagtag acaagctata caaggtggag aacaagccag ccctcagctc caatgaacaa ttgtgcttct tggtcagacc ccgcatcaag aatatgcgat acattgccag tcttgtcaat gctgacaaat tggctggccg aactcgcaaa tacaaagtga tcttcagccc tcaaaagttc tatgcgtgtg agatggtgct tgaggaagag ggaatctatg gagatgtgag ctgtgatgaa tgggccttct ctttgctgcc tcttgatgtg gatctgctga gcatggaact accagaattt ttcagggatt actttctgga aggagatcag cgttggatca acactgtagc tcaggcctta caccttctca gcactctcta tggacccttt ccaaactgct atggaattgg caggtgcgcc aagatggcat atgaattgtg gaggaacctg gaggaggagg aggatggcga aaccaagggc cgaaggccag agattggaca tatctttctc ttggacagag atgtggactt tgtgacagca ctttgctccc aagtggttta tgagggccta gtagatgaca ccttccgcat caagtgtggg agtgtcgact ttggcccaga agtcacatcc tctgacaaga gcctgaaggt gctactcaat gccgaggaca aggtgtttaa tgagattcgg aacgagcact tctccaatgt ctttggcttc ttgagccaga aggcccggaa cttgcaggcc cagtatgatc gccggagagg catggacatt aagcagatga agaatttcgt gtcccaggag ctcaagggcc tgaaacagga gcaccgcctg ctgagtctcc atattggggc ctgtgaatcc atcatgaaga agaaaaccaa gcaggatttc caggagctaa tcaagactga gcatgcactg ctagaggggt tcaacatccg ggagagcacc agctacattg aggaacacat agaccggcag gtgtcgccta tagaaagcct gcgcctcatg tgccttttgt ccatcactga gaatggtttg atccccaagg attaccgatc tctgaaaaca cagtatctgc agagctatgg ccctgagcac ctgctaacct tctccaatct gcgaagagct gggctcctaa cggagcaggc ccccggggac accctcacag ccgtggagag taaagtgagc aagctggtga ccgacaaggc tgcaggaaag attactgatg ccttcagttc tctggccaag aggagcaatt ttcgtgccat cagcaaaaag ctgaatttga tcccacgtgt ggacggcgag tatgatctga aagtgccccg agacatggct tacgtcttca gtggtgctta tgtgcccctg agctgccgaa tcattgagca ggtgctagag cggcgaagct ggcagggcct tgatgaggtg gtacggctgc tcaactgcag tgactttgca ttcacagata tgactaagga agacaaggct tccagtgagt ccctgcgcct catcttggtg gtgttcttgg gtggttgtac attctctgag atctcagccc tccggttcct gggcagagag aaaggctaca ggttcatttt cctgacgaca gcagtcacaa acagcgctcg ccttatggag gccatgagtg aggtgaaagc Protein function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes. [The UniProt Consortium]