VPS26B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1011 Sequence: atgagcttct tcggcttcgg gcagagcgtg gaggtggaaa tccttctgaa cgatgcagag agtaggaagc gggccgagca caagacggag gacgggaaga aggagaaata tttcctcttc tacgacgggg agacggtctc cgggaaggtg agccttgccc tcaagaaccc caacaagcgg ctggagcacc agggcatcaa gatcgagttc atcgggcaga tcgaactcta ctacgatcgc gggaaccacc atgagtttgt gtccctggtg aaggacctgg cccggcctgg agagatcacc cagtcgcagg ccttcgactt tgagtttacc cacgtggaga agccgtatga gtcctacaca gggcagaatg tgaagctacg ctatttcctt cgtgctacca tcagccgccg cctcaatgat gttgtcaaag agatggacat tgtagttcac acactcagca catacccaga gctgaactct tccatcaaga tggaggttgg gattgaggac tgtctgcaca ttgaatttga gtacaataaa tccaaatacc acttgaaaga tgtcattgta gggaagatat acttcctgct ggtgagaatc aaaatcaagc acatggagat agacatcatc aagcgagaaa cgacgggtac aggccccaac gtgtaccatg agaatgacac gatagccaag tacgagatca tggacggggc accagtgcga ggagagtcca tcccgatccg gctcttcctg gccgggtatg agctcacgcc caccatgcgg gacatcaaca agaagttctc tgtgcgctat tacctcaacc tggtgctgat agacgaggag gagcggcgct acttcaagca gcaggaagtg gtgttgtggc ggaagggtga catcgtacgg aagagcatgt cccaccaggc ggccatcgcc tcacagcgct ttgagggcac cacctccctg ggtgaggtgc ggacccccag ccagctgtct gacaacaact gcaggcagta Protein function: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. [The UniProt Consortium]