USP49 (Vector pUC, Accession No. BC014176)

Length: 1923 Sequence: atggatagat gcaaacatgt agggcggtta cggctcgccc aggaccactc catcctgaac cctcagaagt ggtgctgctt agagtgtgcc accaccgagt ccgtgtgggc ctgcctcaag tgctcccacg tggcctgcgg ccgctatatt gaggaccacg ccctgaaaca ctttgaggag acgggacacc cgctagccat ggaagtccgg gatctctacg tgttctgtta cctgtgcaag gactacgtgc tcaatgataa cccagagggg gacctgaagc tgctaagaag ctccctcctg gcggtccggg gccagaaaca ggacacgccg gtgagacgtg ggcggacgct gcggtccatg gcttcgggtg aggacgtggt cctgccgcag cgcgctcctc agggacagcc gcagatgctc acggctctgt ggtaccggcg tcagcgcctg ctggccagga cgctgcggct gtggttcgag aagagctccc ggggccaggc gaagctggag cagcggcggc aggaggaggc cctggagcgc aagaaggagg aggcgcggag gcggcggcgc gaggtgaaac ggcggctgct ggaggagctg gccagcaccc ctccgcgcaa gagtgcacgg ctgctcctgc acacgccccg cgacgcgggc ccggctgcct cgcgccccgc cgccctccct acctcacgca gagtgcccgc cgccacactc aagctgcgtc gccagccggc catggcccca ggcgtcacgg gcctgcgcaa cctgggcaac acctgctaca tgaactccat cctccaggtg ctcagccacc tccagaagtt ccgagaatgt ttcctcaacc ttgacccttc caaaacggaa catctgtttc ccaaagccac caacgggaag actcagcttt ctggcaagcc aaccaacagc tcggccacgg agctgtcctt gagaaatgac agggccgagg catgcgagcg ggagggcttc tgctggaacg gcagggcctc cattagtcgg agtctggagc tcatccagaa caaggagccg agttcaaagc acatttccct ctgccgtgaa ctgcacaccc tcttccgagt catgtggtcc gggaagtggg ccctagtgtc gcccttcgcc atgctgcact cagtgtggag cctgatccct gccttccgcg gctacgacca acaggacgcg caggaatttc tctgcgagct gctgcacaag gtgcagcagg aactcgagtc tgagggcacc acacgccgga tcctcatccc cttctcccag aggaagctca ccaaacaggt cttaaaggtg gtgaatacca tatttcatgg gcagctgctc agtcaggtca catgtatatc atgcaattac aaatccaata ccattgagcc cttttgggac ctatccctgg aattccctga acgctatcac tgcatagaaa aggggtttgt ccctttgaat caaacagagt gcttgctcac tgagatgctg gccaaattca cagagacaga ggccctggaa gggagaatct acgcttgtga ccagtgtaac agcaaacgac gaaaatccaa tcccaaaccc cttgttctga gtgaagctag aaagcagtta atgatctaca gactacctca ggttctccgg ctgcacctta aaagattcag gtggtctggc cgtaatcatc gagagaagat tggggtccat gtcgtctttg accaggtatt aaccatggaa ccttactgct gcagggacat gctctcctct cttgacaaag agacctttgc ctatgatctc tccgcagtgg tcatgcatca cgggaaaggg tttggctcag gacactacac agcctattgc tacaacacag agggaggtgc gtgcgcttta ctctgtgggg tgggggacac ggaaaggggt Protein function: Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. [The UniProt Consortium]