USP30 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1527 Sequence: atgaccgcgg ccgacagggc catccagcgc ttcctgcgga ccggggcggc cgtcagatat aaagtcatga agaactgggg agttataggt ggaattgctg ctgctcttgc agcaggaata tatgttattt ggggtcccat tacagaaaga aagaagcgta gaaaagggct tgtgcctggc cttgttaatt tagggaacac ctgcttcatg aactccctgc tacaaggcct gtctgcctgt cctgctttca tcaggtggct ggaagagttc acctcccagt actccaggga tcagaaggag cccccctcac accagtattt atccttaaca ctcttgcacc ttctgaaagc cttgtcctgc caagaagtta ctgatgatga ggtcttagat gcaagctgct tgttggatgt cttaagaatg tacagatggc agatctcatc atttgaagaa caggatgctc acgaattatt ccatgtcatt acctcgtcat tggaagatga gcgagaccgc cagcctcggg tcacacattt gtttgatgtg cattccctgg agcagcagtc agaaataact cccaaacaaa ttacctgccg cacaagaggg tcacctcacc ccacatccaa tcactggaag tctcaacatc cttttcatgg aagactcact agtaatatgg tctgcaaaca ctgtgaacac cagagtcctg ttcgatttga tacctttgat agcctttcac taagtattcc agccgccaca tggggtcacc cattgaccct ggaccactgc cttcaccact tcatctcatc agaatcagtg cgggatgttg tgtgtgacaa ctgtacaaag attgaagcca agggaacgtt gaacggggaa aaggtggaac accagaggac cacttttgtt aaacagttaa aactagggaa gctccctcag tgtctctgca tccacctaca gcggctgagc tggtccagcc acggcacgcc tctgaagcgg catgagcacg tgcagttcaa tgagttcctg atgatggaca tttacaagta ccacctcctt ggacataaac ctagtcaaca caaccctaaa ctgaacaaga acccagggcc tacactggag ctgcaggatg ggccgggagc ccccacacca gttctgaatc agccaggggc ccccaaaaca cagattttta tgaatggcgc ctgctcccca tctttattgc caacgctgtc agcgccgatg cccttccctc tcccagttgt tcccgactac agctcctcca catacctctt ccggctgatg gcagttgtcg tccaccatgg agacatgcac tctggacact ttgtcactta ccgacggtcc ccaccttctg ccaggaaccc tctctcaact agcaatcagt ggctgtgggt ctccgatgac actgtccgca aggccagcct gcaggaggtc ctgtcctcca gcgcctacct gctgttctac gagcgcgtcc tttccaggat gcagcaccag agccaggagt gcaagtctga Protein function: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2. [The UniProt Consortium]