UBE3C (Vector pENTR223.1, Accession No. BC026241)

Length: 1215 Sequence: atgttcagct tcgaaggcga cttcaagacg cggcccaagg tgtcccttgg cggcgcgagc aggaagtatt ccatccaaag aagtgcattt gatcgctgtg ctaccttgtc acagtccggg ggcgcttttc ccattgctaa tggccccaac cttacccttt tggtaaggca gcttctgttt ttttacaaac aaaatgaaga ctcaaaacgt ttgatatggc tgtatcagaa cttaattaaa cacagctctc tgtttgtcaa gcagttggat ggatctgaga gacttacatg cttatttcag ataaaaagat tgatgagcct ctgttgcagg ttgctgcaaa actgtaatga tgacagtttg aatgttgcac ttccaatgag aatgcttgaa gtattttcgt ctgagaatac ttacttgcct gttttacaag atgctagcta tgtggtgtca gtgattgaac aaattttgca ctacatgatt cacaatgggt attataggtc tctatatttg ttgattaaca gcaagcttcc atcaagtatt gaatattctg atttatctcg agttcctata gcaaaaattt tgctagagaa tgttctaaaa ccattgcact ttacttacaa ctcctgtccg gaaggtgcga ggcaacaagt ttttacagcc ttcacagagg agtttctggc agcacctttt acagatcaga tttttcattt catcattccg gcgcttgcag atgcgcagac cgttttccct tacgagccct ttctgaatgc actgttgtta atagagagta gatgttcaag aaagagtggt ggagcaccct ggcttttcta tttcgtttta actgttggcg aaaattattt gggggccctc tctgaggaag ggctgctggt gtatttgcgg gtgctgcaga ccttcctctc tcagttacca gtctctcctg ccagcgcgag ctgtcacgac tcagccagtg actctgagga ggagagtgaa gaagccgaca agccctcaag cccggaggat ggcagactgt cagtatcata cataacagag gaatgcctga agaagctgga cacaaagcag cagaccaaca ccctgctcaa cctggtgtgg agggactctg cgagcgagga ggtcttcacc accatggcct ccgtctgcca cacgctgatg gtgcagcacc gcatgatggt acccaaagtc agggtgtaca Protein function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys- 48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. [The UniProt Consortium]