UBE3C (Vector pENTR223.1, Accession No. BC014029)

Length: 1950 Sequence: atgttcagct tcgaaggcga cttcaagacg cggcccaagg tgtcccttgg cggcgcgagc aggaaggagg aaaaggcttc tcttttacat cgtactcagg aagaaagaag aaagagagag gaagaaaggc gaaggttgaa aaatgcaata attatccagt catttattcg aggctataga gacagaaaac agcaatattc catccaaaga agtgcatttg atcgctgtgc taccttgtca cagtccgggg gcgcttttcc cattgctaat ggccccaacc ttaccctttt ggtaaggcag cttctgtttt tttacaaaca aaatgaagac tcaaaacgtt tgatatggct gtatcagaac ttaattaaac acagctctct gtttgtcaag cagttggatg gatctgagag acttacatgc ttatttcaga taaaaagatt gatgagcctc tgttgcaggt tgctgcaaaa ctgtaatgat gacagtttga atgttgcact tccaatgaga atgcttgaag tattttcgtc tgagaatact tacttgcctg ttttacaaga tgctagctat gtggtgtcag tgattgaaca aattttgcac tacatgattc acaatgggta ttataggtct ctatatttgt tgattaacag caagcttcca tcaagtattg aatattctga tttatctcga gttcctatag caaaaatttt gctagagaat gttctaaaac cattgcactt tacttacaac tcctgtccgg aaggtgcgag gcaacaagtt tttacagcct tcacagagga gtttctggca gcacctttta cagatcagat ttttcatttc atcattccgg cgcttgcaga tgcgcagacc gttttccctt acgagccctt tctgaatgca ctgttgttaa tagagagtag atgttcaaga aagagtggtg gagcaccctg gcttttctat ttcgttttaa ctgttggcga aaattatttg ggggccctct ctgaggaagg gctgctggtg tatttgcggg tgctgcagac cttcctctct cagttaccag tctctcctgc cagcgcgagc tgtcacgact cagccagtga ctctgaggag gagagtgaag aagccgacaa gccctcaagc ccggaggatg gcagactgtc agtatcatac ataacagagg aatgcctgaa gaagctggac acaaagcagc agaccaacac cctgctcaac ctggtgtgga gggactctgc gagcgaggag gtcttcacca ccatggcctc cgtctgccac acgctgatgg tgcagcaccg catgatggta cccaaagtca ggcttctcta cagtttagcc tttaatgcca ggtttctgag acatctttgg tttctaatat cttccatgtc aacacggatg atcacagggt ctatggtacc gttgcttcag gtgatatcca ggggttctcc tatgtctttt gaagattcta gtcgaatcat cccactcttt taccttttta gctccttgtt tagtcattca ctaatttcca tacatgataa cgaattcttc ggtgatccca tagaagttgt aggtcaaaga caatcatcaa tgatgccttt tactttagaa gagctgataa tgttgtctcg atgccttcga gatgcatgcc tggggatcat caagttggct tatccagaaa ccaagccaga agttcgagaa gaatatatta cagcatttca gagtattgga gttactacta gctctgaaat gcaacaatgc atacagatgg aacagaaaag atggattcag ttatttaagg ttatcaccaa tctagtgaaa atgttgaagt ccagagacac gaggagaaat ttttgtcctc caaaccactg gctgtcagaa caagaagata ttaaagcaga taaggtgtta ttgaaagatc tttttaatat Protein function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys- 48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. [The UniProt Consortium]