TWSG1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 672 Sequence: atgaagttac actatgttgc tgtgcttact ctagccatcc tgatgttcct gacatggctt ccagaatcac tgagctgtaa caaagcactc tgtgctagtg atgtgagcaa atgcctcatt caggagctct gccagtgccg gccgggagaa ggcaattgct cctgctgtaa ggagtgcatg ctgtgtcttg gggccctttg ggacgagtgc tgtgactgtg ttggtatgtg taatcctcga aattatagtg acacacctcc aacttcaaag agcacagtgg aggagctgca tgaaccgatc ccttctctct tccgggcact cacagaagga gatactcagt tgaattggaa catcgtttct ttccctgttg cagaagaact ttcacatcat gagaatctgg tttcattttt agaaactgtg aaccagccac accaccagaa tgtgtctgtc cccagcaata atgttcacgc gccttattcc agtgacaaag aacacatgtg tactgtggtt tattttgatg actgcatgtc catacatcag tgtaaaatat cctgtgagtc catgggagca tccaaatatc gctggtttca taatgcctgc tgcgagtgca ttggtccaga atgtattgac tatggtagta aaactgtcaa atgtatgaac tgcatgtttt Protein function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development. [The UniProt Consortium]