TUSC3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1044 Sequence: atgggggccc ggggcgctcc ttcacgccgt aggcaagcgg ggcggcggct gcggtacctg cccaccggga gctttccctt ccttctcctg ctgctgctgc tctgcatcca gctcggggga ggacagaaga aaaaggagaa tcttttagct gaaaaagtag agcagctgat ggaatggagt tccagacgct caatcttccg aatgaatggt gataaattcc gaaaatttat aaaggcacca cctcgaaact attccatgat tgttatgttc actgctcttc agcctcagcg gcagtgttct gtgtgcaggc aagctaatga agaatatcaa atactggcga actcctggcg ctattcatct gctttttgta acaagctctt cttcagtatg gtggactatg atgaggggac agacgttttt cagcagctca acatgaactc tgctcctaca ttcatgcatt ttcctccaaa aggcagacct aagagagctg atacttttga cctccaaaga attggatttg cagctgagca actagcaaag tggattgctg acagaacgga tgttcatatt cgggttttca gaccacccaa ctactctggt accattgctt tggccctgtt agtgtcgctt gttggaggtt tgctttattt gagaaggaac aacttggagt tcatctataa caagactggt tgggccatgg tgtctctgtg tatagtcttt gctatgactt ctggccagat gtggaaccat atccgtggac ctccatatgc tcataagaac ccacacaatg gacaagtgag ctacattcat gggagcagcc aggctcagtt tgtggcagaa tcacacatta ttctggtact gaatgccgct atcaccatgg ggatggttct tctaaatgaa gcagcaactt cgaaaggcga tgttggaaaa agacggataa tttgcctagt gggattgggc ctggtggtct tcttcttcag ttttctactt tcaatatttc gttccaagta ccacggctat ccttatagct ttttaattaa Protein function: Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues, in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. [The UniProt Consortium]