TSHZ3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2697 Sequence: ATGCTCCCGG AGCCCAGCCT CTTCAGCACC GTGCAGCTGT ACCGGCAGAG CAGCAAGCTC TATGGCTCCA TCTTCACGGG GGCCAGCAAG TTCCGCTGTA AGGACTGCAG CGCTGCCTAC GACACCCTGG TGGAGTTGAC GGTGCACATG AACGAGACGG GGCATTACCG CGACGACAAC CATGAGACCG ATAACAACAA CCCCAAGCGC TGGTCCAAGC CTCGCAAACG CTCCTTGCTG GAAATGGAAG GGAAGGAAGA CGCCCAGAAG GTGCTGAAGT GCATGTACTG TGGCCACTCC TTTGAGTCCC TGCAGGATTT GAGTGTCCAT ATGATCAAAA CAAAACACTA CCAAAAAGTG CCTCTGAAGG AACCCGTCAC TCCTGTCGCC GCCAAAATCA TCCCTGCCAC TCGGAAGAAA GCTTCCCTGG AGCTGGAGCT CCCCAGCTCC CCAGATTCCA CAGGTGGAAC CCCCAAAGCC ACCATCTCAG ACACCAACGA TGCACTTCAG AAGAACTCCA ACCCTTACAT CACGCCAAAT AATCGGTACG GCCACCAGAA TGGGGCCAGC TATGCATGGC ACTTTGAGGC CCGGAAGTCG CAGATCCTGA AGTGCATGGA GTGTGGGAGC TCGCATGACA CCCTGCAGGA GCTCACTGCC CACATGATGG TCACTGGCCA CTTCATCAAG GTCACCAACT CTGCTATGAA AAAGGGGAAG CCCATTGTGG AGACGCCTGT CACACCTACC ATCACAACCC TGCTGGATGA GAAGGTCCAG TCCGTGCCCC TGGCAGCCAC CACCTTCACG TCCCCCTCCA ATACACCTGC CAGCATCTCC CCAAAACTGA ATGTGGAGGT CAAGAAGGAA GTCGACAAGG AGAAAGCGGT CACTGACGAG AAACCTAAGC AAAAAGACAA GCCTGGCGAA GAAGAGGAGA AGTGTGACAT CTCTTCCAAA TACCATTACT TGACTGAAAA TGACTTAGAA GAGAGTCCCA AGGGGGGGCT TGATATCCTC AAATCCTTGG AAAACACAGT GACATCCGCA ATCAACAAGG CCCAGAACGG CACTCCTAGC TGGGGGGGCT ATCCCAGCAT CCATGCCGCC TACCAACTTC CCAACATGAT GAAGTTGTCC CTGGGCTCGT CGGGGAAGAG CACGCCCCTG AAACCCATGT TTGGCAACAG TGAGATTGTC TCCCCGACGA AAAACCAGAC CCTGGTCTCT CCACCCAGCA GCCAGACGTC CCCCATGCCC AAGACAAACT TTCATGCCAT GGAGGAGCTG GTGAAAAAGG TCACTGAGAA AGTTGCCAAA GTGGAGGAGA AGATGAAGGA GCCGGATGGG AAGCTTTCCC CGCCCAAGCG GGCCACTCCC TCCCCATGTA GCAGCGAAGT CGGGGAACCC ATCAAGATGG AGGCATCCAG CGATGGGGGC TTCCGCAGCC AGGAGAACAG CCCCAGCCCC CCGCGGGATG GGTGCAAGGA TGGGAGCCCC CTCGCTGAGC CGGTGGAGAA TGGCAAGGAG CTGGTGAAGC CCCTAGCCAG CAGTTTGAGT GGCAGCACGG CCATCATCAC CGACCACCCG CCTGAACAGC CTTTTGTTAA CCCTTTGAGC GCCCTGCAGT CAGTCATGAA CATTCACCTG GGCAAGGCCG CCAAGCCCTC CCTGCCTGCC CTGGACCCCA TGAGCATGCT TTTCAAGATG AGCAACAGCC TGGCGGAGAA GGCTGCTGTG GCCACCCCGC CGCCCCTGCA GTCCAAGAAG GCAGACCACC TCGACCGCTA TTTCTACCAC GTCAACAACG ACCAGCCCAT AGACTTGACA AAAGGGAAGA GTGACAAAGG CTGCTCCTTG GGTTCAGTGC TTCTGTCACC CACGTCCACA GCCCCGGCAA CCTCCTCATC CACGGTGACA ACGGCAAAGA CATCTGCCGT CGTATCATTC ATGTCAAACT CGCCGCTACG CGAGAATGCC TTGTCAGATA TATCCGATAT GCTGAAGAAC TTGACAGAGA GCCACACGTC AAAATCCTCC ACTCCTTCCA GCATCTCCGA GAAGTCTGAC ATTGACGGGG CCACTCTGGA GGAGGCTGAG GAGTCGACGC CCGCCCAGAA GAGGAAGGGC CGCCAGTCAA ACTGGAACCC CCAGCACCTC CTGATCCTCC AGGCCCAGTT TGCCGCCAGC CTCCGGCAGA CCTCAGAAGG GAAGTACATC ATGTCAGACC TGAGCCCCCA GGAGCGGATG CATATCTCCA GGTTCACCGG GCTGTCCATG ACCACCATCA GCCACTGGCT GGCCAACGTG AAATACCAGC TTCGAAGGAC AGGTGGAACA AAGTTCCTCA AAAACTTGGA CACTGGCCAC CCCGTCTTCT TTTGTAACGA TTGTGCGTCC CAAATCAGGA CTCCTTCCAC GTACATCAGT CACCTAGAGT CACACTTAGG CTTCCGGCTA CGGGACTTAT CCAAACTGTC CACCGAACAG ATTAACAGTC AGATAGCACA AACCAAGTCA CCGTCAGAAA AAATGGTGAC GTCCTCCCCC GAGGAAGACC TGGGGACTTC CTATCAGTGC AAACTTTGCA ATCGGACCTT TGCCAGCAAG CACGCTGTTA AACTTCACCT TAGCAAAACA CACGGGAAAT CTCCGGAAGA CCACCTTCTG TATGTCTCTG AGTTAGAGAA Protein function: Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation. [The UniProt Consortium]