TRIP12 (Vector pUC, Accession No. BC114556)

Length: 6123 Sequence: ATGTCCAACC GGCCTAATAA CAATCCAGGG GGGTCACTGC GACGTTCACA GAGGAACACT GCCGGGGCCC AACCACAAGA CGACTCAATA GGAGGAAGGT CACATTTAGG GCAGGCAAAA CATAAGGGAT ATAGCCCTCC TGAGAGTAGA AAATCTAATT CTAAGGCACC CAAAGTGCAG TCTAATACTA CTTCTGAACT GTCAAGGGGA CACCTTTCTA AAAGAAGCTG CAGTTCATCA TCTGCTGTGA TAGTTCCACA ACCAGAGGAT CCAGACAGAG CCAATACTTC AGAAAGACAA AAAACGGGGC AGGTGCCTAA GAAAGACAAT TCTCGAGGAG TGAAGCGCAG TGCTAGTCCA GACTACAACA GGACCAATTC TCCTAGCTCT GCAAAAAAAC CAAAAGCACT TCAGCATACT GAATCTCCCT CAGAAACAAA TAAGCCACAT AGTAAGTCAA AGAAGAGACA TTTAGACCAG GAGCAACAAC TGAAATCTGC ACAATCACCA TCAACAAGCA AGGCTCATAC CAGGAAGAGT GGGGCCACTG GCGGTTCACG GAGTCAGAAA AGAAAAAGGA CAGAGAGTTC TTGTGTAAAG AGTGGCTCCG GGTCTGAATC AACTGGTGCA GAAGAGAGAT CTGCGAAACC TACCAAGCTG GCTTCAAAAT CAGCCACCTC AGCCAAAGCT GGGTGTAGCA CCATCACTGA TTCTTCTTCT GCTGCCTCTA CTTCCTCCTC GTCTTCTGCT GTAGCCTCGG CCTCCTCCAC TGTACCACCA GGTGCCAGAG TGAAACAAGG AAAAGATCAG AACAAGGCCA GGCGTTCCCG TTCAGCGTCC AGTCCCAGCC CCAGAAGAAG TAGCAGGGAA AAGGAACAGA GTAAAACTGG TGGCTCTTCA AAATTTGATT GGGCTGCTCG TTTCAGCCCT AAAGTTAGCC TTCCTAAAAC AAAACTGTCT CTTCCAGGGT CTTCTAAGTC AGAGACATCA AAACCTGGAC CTTCTGGATT ACAGGCCAAA TTAGCAAGTT TAAGAAAATC TACGAAGAAA CGCAGTGAGT CTCCACCTGC TGAGCTCCCC AGTTTGAGGC GGAGCACACG CCAAAAGACC ACGGGCTCCT GTGCTAGTAC CAGTCGGCGA GGCTCTGGCC TGGGCAAAAG AGGAGCAGCT GAAGCTCGTC GACAGGAGAA AATGGCAGAC CCTGAAAGCA ACCAGGAGGC AGTAAATTCT TCAGCTGCTC GGACAGATGA AGCTCCCCAA GGAGCTGCAG CCTCTAGTTC TGTTGCAGGG GCTGTTGGCA TGACCACCTC TGGGGAGAGT GAATCAGATG ATTCCGAGAT GGGACGTTTG CAAGCTTTGT TAGAGGCAAG GGGTCTTCCC CCTCACCTAT TTGGTCCTCT TGGTCCTCGG ATGTCACAGC TTTTCCATAG AACAATTGGA AGTGGAGCTA GTTCTAAGGC CCAGCAGCTA CTACAAGGAT TGCAAGCCAG TGATGAAAGT CAACAGCTTC AGGCAGTTAT TGAGATGTGT CAGTTACTGG TCATGGGAAA TGAGGAGACA CTGGGAGGGT TTCCTGTCAA GAGTGTTGTT CCAGCTTTGA TTACGTTACT TCAGATGGAG CACAATTTTG ATATTATGAA CCATGCTTGT CGAGCCTTAA CATACATGAT GGAAGCACTT CCTCGATCTT CTGCTGTTGT AGTAGATGCT ATTCCTGTCT TTTTAGAAAA GCTGCAAGTT ATTCAGTGTA TTGATGTGGC AGAGCAGGCC TTGACTGCCT TGGAGATGTT GTCACGGAGA CATAGTAAAG CCATTCTACA GGCGGGTGGT TTGGCAGACT GCTTGCTGTA CCTAGAATTC TTCAGCATAA ATGCCCAAAG AAATGCATTA GCAATTGCAG CTAATTGCTG CCAGAGTATC ACGCCAGATG AATTTCATTT TGTGGCAGAT TCACTCCCAT TGCTAACCCA AAGGCTAACA CATCAGGATA AAAAGTCAGT AGAAAGCACT TGCCTTTGTT TTGCACGCCT AGTGGACAAC TTCCAGCATG AGGAGAATTT ACTCCAGCAG GTTGCTTCCA AAGATCTGCT TACAAATGTT CAACAGCTGT TGGTAGTGAC TCCACCCATT TTAAGTTCTG GGATGTTTAT AATGGTGGTT CGCATGTTTT CTCTGATGTG TTCCAACTGT CCAACTTTAG CTGTTCAACT TATGAAACAA AACATTGCAG AAACGCTTCA CTTTCTCCTG TGTGGTGCCT CCAATGGAAG TTGTCAGGAA CAGATTGATC TTGTTCCACG AAGCCCTCAA GAGTTGTATG AACTGACATC TCTGATTTGT GAACTTATGC CATGTTTACC AAAAGAAGGC ATTTTTGCAG TTGATACCAT GTTGAAGAAG GGAAATGCAC AGAACACAGA TGGTGCGATA TGGCAGTGGC GTGATGATCG GGGCCTCTGG CATCCATATA ACAGGATTGA CAGCCGGATC ATTGAGCAAA TCAATGAGGA CACGGGAACA GCACGTGCCA TTCAGAGAAA ACCTAACCCG TTAGCCAATA GTAACACTAG TGGATATTCA GAGTCAAAGA AGGATGATGC TCGAGCACAG CTTATGAAAG AGGATCCGGA ACTGGCTAAG TCTTTTATTA AGACGTTATT TGGTGTTCTT TATGAAGTGT ATAGTTCCTC AGCAGGACCT GCGGTCAGAC ATAAGTGCCT TAGAGCAATT CTTAGGATAA TTTATTTTGC GGATGCTGAA CTTCTGAAGG ATGTTCTGAA AAATCATGCT GTTTCAAGTC ACATTGCTTC CATGCTGTCA AGCCAAGACC TGAAGATAGT AGTGGGAGCA CTTCAGATGG CAGAAATTTT AATGCAGAAG TTACCTGATA TTTTTAGTGT TTACTTCAGA AGAGAAGGTG TAATGCATCA AGTAAAACAC TTAGCAGAAT CAGAGTCTTT GTTGACAAGT CCACCAAAGG CATGTACGAA TGGATCGGGA TCCATGGGAT CCACAACTTC AGTCAGCAGT GGGACAGCCA CAGCTGCCAC TCATGCTGCA GCTGACTTGG GATCACCCAG CTTGCAGCAC AGCAGGGATG ATTCTTTAGA TCTCAGCCCT CAAGGTCGAT TAAGTGATGT TCTAAAGAGA AAACGACTGC CAAAACGAGG GCCAAGAAGG CCAAAGTACT CACCTCCAAG AGATGATGAC AAAGTAGACA ATCAAGCTAA AAGCCCCACC ACTACTCAGT CACCTAAATC TTCTTTCCTG GCAAGCTTGA ATCCAAAAAC ATGGGGAAGG TTAAGTACAC AGTCCAACAG CAACAACATT GAGCCAGCAC GGACTGCGGG AGGTAGTGGC CTTGCCAGGG CTGCCTCAAA GGATACCATC TCCAATAATA GAGAAAAAAT TAAAGGTTGG ATTAAGGAGC AGGCACATAA ATTTGTAGAA CGTTATTTCA GTTCTGAGAA TATGGATGGA AGCAACCCTG CATTGAATGT CCTTCAGAGA CTTTGTGCTG CAACCGAACA ACTCAACCTC CAGGTGGATG GTGGAGCTGA GTGCCTTGTA GAAATCCGTA GCATAGTCTC AGAGTCAGAT GTTTCATCAT TTGAAATCCA ACATAGTGGA TTTGTGAAGC AGCTGTTGCT TTATTTGACA TCTAAAAGTG AAAAGGATGC TGTGAGCAGA GAGATCAGAT TAAAGCGATT TCTTCATGTA TTTTTTTCTT CTCCACTTCC TGGAGAAGAG CCCATTGGAA GAGTGGAACC AGTGGGTAAT GCACCTTTGT TGGCATTAGT TCACAAGATG AACAACTGCC TCAGCCAGAT GGAACAATTT CCAGTCAAAG TACATGATTT CCCTAGTGGA AATGGGACAG GAGGCAGCTT TTCTCTCAAC AGAGGATCAC AGGCTTTAAA ATTTTTCAAC ACACATCAAT TAAAATGCCA GTTACAAAGG CATCCAGACT GTGCAAATGT GAAGCAGTGG AAGGGTGGAC CTGTCAAGAT TGACCCTCTG GCTTTGGTAC AAGCCATCGA GAGATACCTT GTAGTTAGAG GGTATGGAAG AGTAAGAGAA GATGATGAAG ACAGCGATGA CGATGGATCA GATGAGGAAA TAGATGAGTC TCTGGCTGCT CAGTTCCTAA ATTCAGGAAA TGTAAGACAC AGGCTGCAGT TTTATATTGG AGAACATTTG CTGCCGTATA ACATGACTGT GTATCAGGCA GTACGGCAGT TTAGTATACA GGCTGAAGAT GAAAGAGAAT CCACAGATGA TGAGAGCAAT CCTCTAGGCA GAGCTGGTAT TTGGACAAAG ACTCATACAA TATGGTATAA ACCTGTGAGA GAGGATGAAG AAAGTAATAA AGATTGTGTT GGTGGTAAAA GAGGAAGAGC CCAAACAGCT CCAACGAAAA CTTCCCCTAG AAATGCAAAA AAGCATGATG AGTTATGGCA CGATGGAGTG TGCCCATCAG TATCAAATCC TTTAGAAGTT TACCTCATTC CCACACCACC TGAAAATATA ACATTTGAAG ACCCGTCATT AGATGTGATC CTTCTTTTAA GAGTTTTACA TGCTATCAGT CGATACTGGT ATTACTTGTA TGATAATGCA ATGTGCAAGG AAATTATTCC AACTAGTGAA TTTATTAACA GTAAGTTAAC AGCAAAAGCA AATAGGCAAC TTCAAGATCC TTTAGTAATC ATGACAGGAA ACATCCCAAC ATGGCTTACT GAGCTAGGAA AAACCTGCCC ATTTTTCTTT CCTTTTGATA CCCGGCAAAT GCTTTTTTAT GTAACTGCAT TTGATCGGGA CCGAGCAATG CAAAGATTAC TTGATACCAA CCCAGAAATC AACCAGTCTG ATTCTCAAGA TAGCAGAGTT GCACCTAGAT TGGATAGAAA AAAACGTACT GTGAACCGAG AGGAGCTGCT GAAACAGGCG GAGTCTGTGA TGCAGGACCT CGGCAGCTCA CGGGCCATGT TAGAAATCCA GTATGAAAAT GAGGTTGGTA CAGGTCTTGG GCCTACACTG GAGTTTTATG CGCTTGTATC TCAGGAACTA CAGAGAGCTG ACTTGGGTCT TTGGAGAGGT GAAGAAGTAA CTCTTAGCAA TCCAAAAGGG AGCCAAGAAG GGACCAAGTA TATTCAAAAC CTCCAGGGCC TGTTTGCGCT TCCCTTTGGT AGGACAGCAA AGCCAGCTCA TATCGCAAAG GTTAAGATGA AGTTTCGCTT CTTAGGAAAA TTAATGGCCA AGGCTATCAT GGATTTCAGA TTGGTGGACC TTCCCCTTGG CTTACCCTTT TATAAATGGA TGCTACGGCA AGAAACTTCA CTGACATCAC ACGATTTGTT TGACATCGAC CCAGTTGTAG CCAGATCAGT TTATCACCTA GAAGACATTG TCAGACAGAA GAAAAGACTT GAACAAGATA AATCCCAGAC CAAAGAGAGT CTACAGTATG CATTAGAAAC CTTGACTATG AATGGCTGCT CAGTTGAAGA TCTAGGACTG GATTTCACTC TGCCAGGGTT TCCCAATATC GAACTGAAGA AAGGAGGGAA GGATATACCA GTCACTATCC ACAATTTAGA GGAGTATCTA AGACTGGTTA TATTCTGGGC ACTAAATGAA GGCGTTTCTA GGCAATTTGA TTCGTTCAGA GATGGATTTG AATCAGTCTT CCCACTCAGT CATCTTCAGT ACTTCTACCC GGAGGAACTG GATCAGCTCC TTTGTGGCAG TAAAGCAGAC ACTTGGGATG CAAAGACACT GATGGAATGC TGTAGGCCTG ATCATGGTTA TACTCATGAC AGTCGGGCTG TGAAGTTTTT GTTTGAGATT CTCAGTAGTT TTGATAATGA GCAGCAGAGG TTATTTCTCC AGTTTGTGAC TGGTAGCCCA AGATTGCCTG TTGGAGGATT CCGGAGTTTG AATCCACCTT TGACAATTGT CCGAAAGACG TTTGAATCAA CAGAAAACCC AGATGACTTC TTGCCCTCTG TAATGACTTG TGTGAACTAT CTTAAGTTGC CGGACTATTC AAGCATTGAG ATAATGCGTG AAAAACTGTT GATAGCAGCA AGAGAAGGGC AGCAGTCGTT CCATCTTTCC Protein function: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). [The UniProt Consortium]