TRIM13 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1224 Sequence: atggagctgc ttgaagaaga tctcacatgc cctatttgtt gtagtctgtt tgatgatcca cgggttttgc cttgctccca caacttctgc aaaaaatgct tagaaggtat cttagaaggg agtgtgcgga attccttgtg gagaccagct ccattcaagt gtcctacatg ccgtaaggaa acttcagcta ctggaattaa tagcctgcag gttaattact ccctgaaggg tattgtggaa aagtataaca agatcaagat ctctcccaaa atgccagtat gcaaaggaca cttggggcag cctctcaaca ttttctgcct gactgatatg cagctgattt gtgggatctg tgctactcgt ggggagcaca ccaaacatgt cttctgttct attgaagatg cctatgctca ggaaagggat gcctttgagt ccctcttcca gagctttgag acctggcgtc ggggagatgc tctttctcgc ttggatacct tggaaactag taagaggaaa tccctacagt tactgactaa agattcagat aaagtgaagg aattttttga gaagttacaa cacacactgg atcaaaagaa gaatgaaatt ctgtctgact ttgagaccat gaaacttgct gttatgcaag catatgaccc agagatcaac aaactcaaca ccatcttgca ggagcaacgg atggccttta acattgctga ggctttcaaa gatgtgtcag aacccattgt atttctgcaa cagatgcagg agtttagaga gaaaatcaaa gtaatcaagg aaactccttt acctccctct aatttgcctg caagcccttt aatgaagaac tttgatacca gtcagtggga agacataaaa ctagtcgatg tggataaact ttctttgcct caagacactg gcacattcat tagcaagatt ccctggagct tttataagtt atttttgcta atccttctgc ttggccttgt cattgtcttt ggtcctacca tgttcctaga atggtcatta tttgatgacc tggcaacttg gaaaggctgt ctttcaaact tcagttccta tctgactaaa acagccgatt tcatagaaca atcagttttt tactgggaac aggtgacaga tgggtttttc attttcaatg aaagattcaa gaattttact ttggtggtac tgaacaatgt ggcagaattt gtgtgcaaat ataaactatt Protein function: Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor- mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375). [The UniProt Consortium]