TRAM2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1113 Sequence: atggctttcc gcaggaggac gaaaagttac ccgctcttca gccaggagtt cgtcatccac aaccatgcgg acatcggctt ctgcctggtg ctctgcgtcc tcatcgggct tatgttcgag gtcacagcca agactgcctt tctatttatt ttacctcagt ataacattag cgtgcctaca gcagacagtg agaccgtgca ctaccactat ggccctaagg acctggtcac aatcttgttc tacatcttca tcaccatcat cttgcatgct gtggttcagg agtacatttt agataaaatc agcaaacggc ttcatctctc caaagtcaaa cacagcaagt tcaatgaatc tggacagctg gtcgtctttc atttcacctc ggtgatttgg tgcttctacg tggtggtgac ggaaggatac ttaacaaacc caagaagcct ctgggaagac tacccgcatg tgcacctccc cttccaggtg aagtttttct acctatgcca gctggcctac tggctgcacg cacttcctga gctatacttc cagaaggtac ggaaggagga aattccccgc cagctccagt atatttgcct gtacctggtg catatagctg gagcatacct cttaaacctg agccgcctgg gcctgatctt gctgctgctg cagtactcaa ctgagttcct cttccacacg gctagactct tctactttgc agatgaaaac aacgagaaac tgttcagtgc ctgggctgct gtttttgggg ttacccgcct cttcatcctc acccttgccg tgctggccat tggctttgga ctggctcgca tggaaaacca ggcatttgat cccgagaaag ggaacttcaa cactttgttt tgcaggctct gcgtgctgct gctggtgtgt gccgcccagg cctggctcat gtggcgcttc atccactccc agctgcggca ctggcgggaa tactggaatg agcagagtgc aaagcggaga gtcccagcca cacccagact accagccagg ctcatcaaga gggaatctgg ttaccatgaa aatggagtgg tgaaggcaga gaacggaacc tccccacgga ctaagaaact caagtctccc Protein function: Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293). [The UniProt Consortium]