TRAF3IP3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 1656 Sequence: atgatcagcc cagaccccag gccctcccct ggcttggccc ggtgggctga gagctatgag gccaagtgtg agcgcaggca agagatccgt gaaagccgcc gctgccgtcc caatgtgacc acttgccgcc aggtggggaa gacgctgagg atccaacaga gagagcagct ccagagagct cgactgcagc agttcttcag gaggaggaac ctggagctag aggagaaggg caaagcgcag catccccagg ccagggagca agggccctcc aggcggccag gacaggtgac tgtcctcaag gaacccttgt cttgtgccag aaggatttct tctcccagag agcaggtgac aggcaccagc tctgaagtct ttccagccca gcatcctcct ccctcaggca tctgcaggga tctgtctgac cacctctcct cacaggctgg gggccttcct ccacaggaca ctcccatcaa gaagccaccc aaacaccacc gtggtactca gacaaaggca gaaggaccaa caattaagaa cgatgccagt cagcaaacca attacggagt tgcagttctg gataaggaaa tcatccagct ttctgattac ctcaaagagg ccctacaaag ggagctggtc ctaaaacaga aaatggtgat tctccaagac ctactgtcca ctctgattca ggcctctgac agctcttgga agggacagct taatgaagac aaactgaagg ggaaactgag atccttagaa aaccagctat acacctgtac ccagaaatac tccccttggg gaatgaaaaa agtactactg gagatggaag accagaaaaa cagctatgag cagaaggcca aggagtcact gcagaaagtg ctggaggaga aaatgaatgc agagcagcaa ctacagagca cacagcgatc cctggccctg gcagagcaga agtgtgaaga gtggaggagc cagtatgagg ctctgaagga ggactggagg acccttggga cccagcacag ggagctggag agccaactcc acgtgcttca gtccaaactg cagggagcag atagcaggga cttacagatg aaccaggccc tgcgattttt ggaaaatgag caccaggaac tgcaggccaa gattgaatgc ctgcaagggg acagagacct gtgcagcttg gatacccagg acctacaaga tcaactaaaa aggtcagagg cagagaaact caccctggtg accagagtac agcagttgca gggtttgctt caaaatcaat ccttacagct tcaagaacag gagaaactct taacaaagaa agatcaggct ttgcccgtgt ggagtccaaa gtccttccct aacgaagtgg agcctgaggg tacagggaag gagaaagact gggatctcag agaccagctg caaaagaaga ctttgcagct ccaggccaag gaaaaggagt gcagagaact gcattcagaa ttagacaacc tcagtgacga gtatctctcc tgcctgcgta agctgcagca ctgtcgagaa gagctgaacc agagccagca gctgcctccc agaaggcaat gtgggcgatg gctcccagtg ctgatggtgg tgattgctgc agcactggca gtgttcctgg ccaataaaga caacctgatg Protein function: Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Plays also an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'- dependent ubiquitination of TBK1 (PubMed:32366851). [The UniProt Consortium]