TRADD (Vector pUC, Accession No. BC004491)

Length: 939 Sequence: atggcagctg ggcaaaatgg gcacgaagag tgggtgggca gcgcatacct gtttgtggag tcctcgctgg acaaggtggt cctgtcggat gcctacgcgc acccccagca gaaggtggca gtgtacaggg ctctgcaggc tgccttggca gagagcggcg ggagcccgga cgtgctgcag atgctgaaga tccaccgcag cgacccgcag ctgatcgtgc agctgcgatt ctgcgggcgg cagccctgtg gccgcttcct ccgcgcctac cgcgaggggg cgctgcgcgc cgcgctgcag aggagcctgg cggccgcgct cgcccagcac tcggtgccgc tgcaactgga gctgcgcgcc ggcgccgagc ggctggacgc tttgctggcg gacgaggagc gctgtttgag ttgcatccta gcccagcagc ccgaccggct ccgggatgaa gaactggctg agctggagga tgcgctgcga aatctgaagt gcggctcggg ggcccggggt ggcgacgggg aggtcgcttc ggcccccttg cagcccccgg tgccctctct gtcggaggtg aagccgccgc cgccgccgcc acctgcccag acttttctgt tccagggtca gcctgtagtg aatcggccgc tgagcctgaa ggaccaacag acgttcgcgc gctctgtggg tctcaaatgg cgcaaggtgg ggcgctcact gcagcgaggc tgccgggcgc tgcgggaccc ggcgctggac tcgctggcct acgagtacga gcgcgaggga ctgtacgagc aggccttcca gctgctgcgg cgcttcgtgc aggccgaggg ccgccgcgcc acgctgcagc gcctggtgga ggcactcgag gagaacgagc tcaccagcct ggcagaggac ttgctgggcc tgaccgatcc caatggcggc Protein function: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF- induced responses, apoptosis and activation of NF-kappa-B. [The UniProt Consortium]