TOX (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, Ac

Length: 1581 Sequence: atggacgtaa gattttatcc acctgtagcc cagcccgccg ctgcgcccga cgctccctgt ctgggacctt ctccctgcct ggacccctac tattgcaaca agtttgacgg tgagaacatg tatatgagca tgacagagcc gagccaggac tatgtgccag ccagccagtc ctaccctggt ccaagcctgg aaagtgaaga cttcaacatt ccaccaatta ctcctccttc cctcccagac cactcgctgg tgcacctgaa tgaagttgag tctggttacc attctctgtg tcaccccatg aaccataatg gcctgctacc atttcatcca caaaacatgg acctccctga aatcacagtc tccaatatgc tgggccagga tggaacactg ctttctaatt ccatttctgt gatgccagat atacgaaacc cagaaggaac tcagtacagt tcccatcctc agatggcagc catgagacca aggggccagc ctgcagacat caggcagcag ccaggaatga tgccacatgg ccagctgact accattaacc agtcacagct aagtgctcaa cttggtttga atatgggagg aagcaatgtt ccccacaact caccatctcc acctggaagc aagtctgcaa ctccttcacc atccagttca gtgcatgaag atgaaggcga tgatacctct aagatcaatg gtggagagaa gcggcctgcc tctgatatgg ggaaaaaacc aaaaactccc aaaaagaaga agaagaagga tcccaatgag ccccagaagc ctgtgtctgc ctatgcgtta ttctttcgtg atactcaggc cgccatcaag ggccaaaatc caaacgctac ctttggcgaa gtctctaaaa ttgtggcttc aatgtgggac ggtttaggag aagagcaaaa acaggtctat aaaaagaaaa ccgaggctgc gaagaaggag tacctgaagc aactcgcagc atacagagcc agccttgtat ccaagagcta cagtgaacct gttgacgtga agacatctca acctcctcag ctgatcaatt cgaagccgtc ggtgttccat gggcccagcc aggcccactc ggccctgtac ctaagttccc actatcacca acaaccggga atgaatcctc acctaactgc catgcatcct agtctcccca ggaacatagc ccccaagccg aataaccaaa tgccagtgac tgtctctata gcaaacatgg ctgtgtcccc tcctcctccc ctccagatca gcccgcctct tcaccagcat ctcaacatgc agcagcacca gccgctcacc atgcagcagc cccttgggaa ccagctcccc atgcaggtcc agtctgcctt acactcaccc accatgcagc aaggatttac tcttcaaccc gactatcaga ctattatcaa tcctacatct acagctgcac aagttgtcac ccaggcaatg gagtatgtgc gttcggggtg cagaaatcct cccccacaac cggtggactg gaataacgac tactgcagta gtgggggcat gcagagggac aaagcactgt accttacttg Protein function: Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis. Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2. Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:21126536). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation- induced cell death. [The UniProt Consortium]