TMPRSS11D (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or p

Length: 1257 Sequence: ATGTATAGGC CAGCACGTGT AACTTCGACT TCAAGATTTC TGAATCCATA TGTAGTATGT TTCATTGTCG TCGCAGGGGT AGTGATCCTG GCAGTCACCA TAGCTCTACT TGTTTACTTT TTAGCTTTTG ATCAAAAATC TTACTTTTAT AGGAGCAGTT TTCAACTCCT AAATGTTGAA TATAATAGTC AGTTAAATTC ACCAGCTACA CAGGAATACA GGACTTTGAG TGGAAGAATT GAATCTCTGA TTACTAAAAC ATTCAAAGAA TCAAATTTAA GAAATCAGTT CATCAGAGCT CATGTTGCCA AACTGAGGCA AGATGGTAGT GGTGTGAGAG CGGATGTTGT CATGAAATTT CAATTCACTA GAAATAACAA TGGAGCATCA ATGAAAAGCA GAATTGAGTC TGTTTTACGA CAAATGCTGA ATAACTCTGG AAACCTGGAA ATAAACCCTT CAACTGAGAT AACATCACTT ACTGACCAGG CTGCAGCAAA TTGGCTTATT AATGAATGTG GGGCCGGTCC AGACCTAATA ACATTGTCTG AGCAGAGAAT CCTTGGAGGC ACTGAGGCTG AGGAGGGAAG CTGGCCGTGG CAAGTCAGTC TGCGGCTCAA TAATGCCCAC CACTGTGGAG GCAGCCTGAT CAATAACATG TGGATCCTGA CAGCAGCTCA CTGCTTCAGA AGCAACTCTA ATCCTCGTGA CTGGATTGCC ACGTCTGGTA TTTCCACAAC ATTTCCTAAA CTAAGAATGA GAGTAAGAAA TATTTTAATT CATAACAATT ATAAATCTGC AACTCATGAA AATGACATTG CACTTGTGAG ACTTGAGAAC AGTGTCACCT TTACCAAAGA TATCCATAGT GTGTGTCTCC CAGCTGCTAC CCAGAATATT CCACCTGGCT CTACTGCTTA TGTAACAGGA TGGGGCGCTC AAGAATATGC TGGCCACACA GTTCCAGAGC TAAGGCAAGG ACAGGTCAGA ATAATAAGTA ATGATGTATG TAATGCACCA CATAGTTATA ATGGAGCCAT CTTGTCTGGA ATGCTGTGTG CTGGAGTACC TCAAGGTGGA GTGGACGCAT GTCAGGGTGA CTCTGGTGGC CCACTAGTAC AAGAAGACTC ACGGCGGCTT TGGTTTATTG TGGGGATAGT AAGCTGGGGA GATCAGTGTG GCCTGCCGGA TAAGCCAGGA GTGTATACTC GAGTGACAGC CTACCTTGAC TGGATTAGGC AACAAACTGG Protein function: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions, spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. [The UniProt Consortium]