TMEM30A (Vector pENTR223.1, Accession No. BC009006)

Length: 978 Sequence: atggcgatga actataacgc gaaggatgaa gtggacggtg ggcccccgtg tgctccgggg ggcaccgcga agactcggag accggataac acggccttca aacagcaacg gctgccagct tggcagccca tccttacggc tggcacggtg ctacctattt tcttcatcat cggtctcatc ttcattccca tcggcattgg catttttgtc acctccaaca acatccgcga gatcgagggc aacgtgttta tgtattatgg actgtctaat ttctatcaaa accatcgtcg ttacgtgaaa tctcgagatg atagtcaact aaatggagat tctagtgctt tgcttaatcc cagtaaggaa tgtgaacctt atcgaagaaa tgaagacaaa ccaattgctc cttgtggagc tattgccaac agcatgttta atgatacatt agaattgttt ctcattggca atgattctta tcctatacct atcgctttga aaaagaaagg tattgcttgg tggacagata aaaatgtgaa attcagaaat ccccctggag gagacaacct ggaagaacga tttaaaggta caacaaagcc tgtgaactgg cttaaaccag tttacatgct ggattctgac ccagataata atggattcat aaatgaggat tttattgttt ggatgcgtac tgcagcatta cctacttttc gcaagttgta tcgtcttata gaaaggaaaa gtgatttaca tccaacatta ccagctggcc gatactcttt gaatgtcaca tacaattacc ctgtacatta ttttgatgga cgaaaacgga tgatcttgag cactatttca tggatgggag gaaaaaatcc atttttgggg attgcttaca tcgctgttgg atccatctcc ttccttctgg gagttgtact gctagtaatt aatcataaat atagaaacag tagtaataca gctgacatta Protein function: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. [The UniProt Consortium]