TLK1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 2301 Sequence: atgagtgtcc aaagtagcag tggaagtttg gaggggccgc catcttggtc ccagctctcc acgtctccaa ccccgggctc ggcggcggcg gccaggtccc tgctgaatca cacgccgcca tccgggaggc ccagggaagg tgcaatggat gagcttcata gtctggatcc aagaaggcaa gagttattgg aagctagatt tactggagtt gcaagtggga gcactggaag tacgggcagt tgcagtgttg gagctaaagc ctcaacaaat aacgaaagct ctaatcacag ttttggaagc ttgggatctt taagtgacaa agaatcagag acaccggaga agaaacaatc ggaatcatcc aggggaagaa agagaaaagc agaaaaccag aatgaaagta gtcagggaaa aagtattggg ggacgtggcc acaaaattag cgactatttt gaataccagg gtggaaatgg ctcaagtcca gtaagaggca tacctcctgc aatccgttct cctcaaaatt cacattcaca ttccactcct tcctcatctg ttcgaccgaa tagcccttct cctactgcat tagcatttgg ggaccaccct attgtacaac caaagcaatt atcctttaaa attattcaga ctgatctcac aatgctgaaa ttagcagcat tagaaagtaa taaaatccag gacctggaaa agaaggaggg acgtatagat gatttgctca gggctaactg tgatctcaga cggcaaatag atgaacaaca aaaattactt gaaaaataca aagaacgatt aaataagtgc atatcaatga gcaagaaact tcttattgaa aagagtacac aagaaaagct gtcaagcaga gagaagagta tgcaagatcg attacgcctt gggcacttta caacagttag acatggcgct tcatttactg aacaatggac agatggtttt gcatttcaga atcttgtgaa gcaacaagaa tgggtgaatc agcaaaggga agatattgaa aggcaaagga aacttctagc caaacgcaaa cctcccacag ctaataattc tcaggcaccc tctaccaatt ctgaaccaaa acaaaggaaa aacaaagcag tcaatggagc agagaatgat ccctttgtta gaccaaattt accacaactg ttgactttgg cagaatatca tgaacaggaa gaaattttca aacttagact aggacatctc aaaaaggaag aggcagaaat ccaggcagaa cttgaacgtt tggaaagagt cagaaatctt cacatacgtg agctgaaaag aataaacaat gaagataatt cacagttcaa agatcaccca acattaaatg aaagatattt attacttcat ctgcttggta gaggtggctt tagtgaagtg tataaggctt ttgaccttta tgaacaaaga tatgctgctg tgaagataca tcagcttaat aaaagctgga gagatgagaa gaaagaaaac taccacaaac atgcctgcag agagtataga atacacaaag aactggatca ccccagaata gttaaactct atgattattt ctccttggat acagatacgt tttgtacagt gttagaatac tgtgaaggca atgacttgga tttctatctg aagcaacaca agttaatgtc agagaaagaa gctcggtcta ttgtaatgca gattgtaaat gcactaagat atctcaatga gatcaaaccc cctattatac attatgatct taagccagga aacatcctac tggtagatgg aacagcatgt ggtgaaatca aaatcactga ttttggtctg tccaagatta tggatgatga tagctatggt gtagatggaa tggatctaac ttcccagggg gcaggcactt actggtattt acctcctgag tgttttgtag ttggaaaaga gccaccaaag atttccaaca aggttgatgt atggtcggtt ggagtcatct tctttcagtg tctttatggt agaaagccat ttggtcacaa tcaatctcaa caagacattc ttcaagaaaa tacaatatta aaagccacag aagtccagtt ccctgtaaaa ccggttgtaa gcagtgaagc caaggcattt ataagacgct gtttggcata tcgaaaagaa gatcgatttg atgtgcacca gctggcaaat gacccatacc ttctcccaca catgagaaga tcaaattctt caggaaacct acacatggct gggctgacag catcccctac acccccttct tcaagcataa ttacttactg Protein function: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. [The UniProt Consortium]