TFB2M (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1191 Sequence: atgtggatcc cagtggtcgg gcttcctcgg cggctgaggc tctccgcctt ggcgggcgct ggtcgctttt gcattttagg gtctgaagcg gcgacgcgaa agcatttgcc ggcgaggaac cactgtgggc tctctgactc ctctccgcag ctgtggcccg aaccggattt caggaatccg ccaaggaagg cgtctaaggc cagcttagac tttaagcgtt acgtaaccga tcggagattg gctgagaccc tggcgcaaat ctatttggga aaaccaagta gacctccaca cctactgctg gagtgcaatc caggtcctgg aatcctgact caggcattac ttgaagctgg tgccaaagtg gttgcgctcg aaagtgacaa aacttttatt ccacatttgg agtccttagg aaaaaatctg gatggaaaac tacgagtgat tcactgtgac ttctttaaac tagatcctag aagtggtgga gtaataaaac cacctgctat gtcttctcga gggctcttta agaatttggg aatagaagca gttccttgga cagcagacat ccctttaaaa gtagttggaa tgttcccaag tagaggtgag aaaagggcac tttggaaact cgcatatgac ttgtattcct gtacttctat atataaattt ggacgaatag aagtaaatat gtttattggt gaaaaagaat tccagaaact aatggcagat cctggaaatc cagacttgta tcatgtatta agtgttatct ggcaattagc ttgtgagatt aaggttctgc acatggagcc ttggtcatca tttgatatat acacccggaa agggccgctg gaaaacccaa agcgtaggga attattagac caattacaac aaaagctgta tcttattcaa atgattcctc gtcaaaattt atttaccaag aacttaacac ctatgaacta taatatattt tttcacttgt taaagcactg ttttgggagg cgcagcgcca ctgtaataga ccacttacgt tcattgactc cacttgatgc gagagatata ttgatgcaaa taggaaaaca ggaggatgag aaagtagtta acatgcaccc tcaagacttc aaaacacttt ttgaaactat agagcgttcc aaagattgtg cttataaatg gctgtatgat gaaaccctgg aagataggta Protein function: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603, PubMed:12068295, PubMed:20410300, PubMed:15526033). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- template strand (PubMed:29149603, PubMed:15526033). Stimulates transcription independently of the methyltransferase activity (PubMed:12897151). [The UniProt Consortium]