TBC1D5 (Vector pUC, Accession No. BC013145)

Length: 2388 Sequence: atgtatcatt ccttatctga aactagacat cctctgcagc cagaagaaca agaagtaggc attgacccct tgtccagtta ctctaacaag tctggaggag attcaaataa aaatggaaga agaacaagtt ctactttaga ctctgaaggg acttttaatt cctataggaa agaatgggaa gaactatttg taaacaacaa ttacttggca acaataaggc agaaggggat taatgggcag ctgagaagca gcaggttccg cagcatttgc tggaagctat ttctttgtgt tcttcctcaa gacaaaagtc aatggataag tagaattgaa gaattaagag catggtatag caacattaaa gaaatacata ttaccaaccc gaggaaggtt gttggccaac aagatttgat gatcaataat cctctttcac aggatgaagg gagtctttgg aacaaattct tccaagataa agaacttcga tcaatgattg aacaagatgt caaaagaacg tttcctgaaa tgcagttttt ccagcaagaa aatgtgagaa aaattcttac agatgttctt ttctgttatg ccagagaaaa cgagcagttg ctttataaac agggcatgca cgaactgtta gcacctatag tctttgtcct tcactgtgac caccaagctt ttctacatgc cagtgagtct gcacagccca gtgaggaaat gaaaactgtc ttgaaccctg agtatctgga acatgatgcc tatgcagtgt tctcacaact tatggaaact gctgaacctt ggttttcaac ttttgagcat gatggtcaga aggggaaaga aacactgatg actcccattc cctttgctag accacaagat ttagggccaa caattgctat tgttactaaa gtcaaccaga tccaggatca tctactgaag aagcatgata ttgagcttta catgcacttg aacagactag aaattgcacc acagatatat gggttaaggt gggtgcggct gctatttgga cgagagttcc ccctgcagga ccttctggtg gtctgggatg ccttgtttgc agacggcctc agcctgggtt tagtagatta tatcttcgta gccatgttac tttacatccg agatgctttg atctctagta actaccagac ctgtctcggc cttctgatgc attacccatt catcggggat gtacactcac tgattcttaa ggctctgttc cttagagatc caaagagaaa tccaagacca gtgacttatc aattccatcc aaatttagat tattacaaag cacgaggagc agacctcatg aataaaagcc ggaccaatgc caaaggtgct cccctgaata taaataaggt ctctaatagc ctgattaatt ttggaagaaa gttgatttcc ccagcaatgg ctccaggcag tgcaggtggc cctgtacctg gaggcaacag cagtagctcc tcctctgttg taattcctac caggacctca gcagaggccc caagccatca cttgcaacag caacagcagc agcagaggct gatgaaatca gaaagcatgc ctgtgcaatt gaacaaaggg ctaagttcta aaaacatcag ttcatctcca agcgttgaga gtttgcctgg aggaagagaa ttcactggct ctccaccttc atctgctact aaaaaagatt ccttttttag caacatctca cgttctcgct cacacagcaa aactatgggc agaaaagaat ctgaagaaga attagaagcc caaatttcct tccttcaagg gcagttgaat gacctggatg ccatgtgcaa atactgtgca aaggtgatgg acactcatct tgtaaatatt caagatgtga tattacaaga aaatttggaa aaagaagatc aaattctggt ttccctggca ggattaaaac agatcaaaga cattctaaaa ggttccctgc gttttaacca gagccagcta gaggccgaag agaacgaaca gatcaccatt gcggacaacc actactgctc cagcggccag ggccagggcc gaggccaagg ccagagcgtt caaatgtcag gggccattaa acaggcctct tcagaaacgc cagggtgcac tgatagaggg aattccgatg acttcatcct gatttccaaa gatgatgatg ggagcagtgc caggggctcc ttctccggcc aggcccagcc tcttcgcacc ctcagaagca cctctgggaa aagccaggcc ccagtctgct ccccactggt gttctcagat ccactgatgg gcccagcctc agcttcctcc agcaacccca gctccagtcc tgatgacgac agcagcaagg actctggctt caccattgtg agtcccctgg Protein function: May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol, at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN), the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). [The UniProt Consortium]