SUV39H1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1239 Sequence: atggcggaaa atttaaaagg ctgcagcgtg tgttgcaagt cttcttggaa tcagctgcag gacctgtgcc gcctggccaa gctctcctgc cctgccctcg gtatctctaa gaggaacctc tatgactttg aagtcgagta cctgtgcgat tacaagaaga tccgcgaaca ggaatattac ctggtgaaat ggcgtggata tccagactca gagagcacct gggagccacg gcagaatctc aagtgtgtgc gtatcctcaa gcagttccac aaggacttag aaagggagct gctccggcgg caccaccggt caaagacccc ccggcacctg gacccaagct tggccaacta cctggtgcag aaggccaagc agaggcgggc gctccgtcgc tgggagcagg agctcaatgc caagcgcagc catctgggac gcatcactgt agagaatgag gtggacctgg acggccctcc gcgggccttc gtgtacatca atgagtaccg tgttggtgag ggcatcaccc tcaaccaggt ggctgtgggc tgcgagtgcc aggactgtct gtgggcaccc actggaggct gctgcccggg ggcgtcactg cacaagtttg cctacaatga ccagggccag gtgcggcttc gagccgggct gcccatctac gagtgcaact cccgctgccg ctgcggctat gactgcccaa atcgtgtggt acagaagggt atccgatatg acctctgcat cttccgcacg gatgatgggc gtggctgggg cgtccgcacc ctggagaaga ttcgcaagaa cagcttcgtc atggagtacg tgggagagat cattacctca gaggaggcag agcggcgggg ccagatctac gaccgtcagg gcgccaccta cctctttgac ctggactacg tggaggacgt gtacaccgtg gatgccgcct actatggcaa catctcccac tttgtcaacc acagttgtga ccccaacctg caggtgtaca acgtcttcat agacaacctt gacgagcggc tgccccgcat cgctttcttt gccacaagaa ccatccgggc aggcgaggag ctcacctttg attacaacat gcaagtggac cccgtggaca tggagagcac ccgcatggac tccaactttg gcctggctgg gctccctggc tcccctaaga agcgggtccg tattgaatgc aagtgtggga ctgagtcctg ccgcaaatac Protein function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. [The UniProt Consortium]