ST8SIA1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1071 Sequence: atgagcccct gcgggcgggc ccggcgacaa acgtccagag gggccatggc tgtactggcg tggaagttcc cgcggacccg gctgcccatg ggagccagtg ccctctgtgt cgtggtcctc tgttggctct acatcttccc cgtctaccgg ctgcccaacg agaaagagat cgtgcagggg gtgctgcaac agggcacggc gtggaggagg aaccagaccg cggccagagc gttcaggaaa caaatggaag actgctgcga ccctgcccat ctctttgcta tgactaaaat gaattcccct atggggaaga gcatgtggta tgacggggag tttttatact cattcaccat tgacaattca acttactctc tcttcccaca ggcaacccca ttccagctgc cattgaagaa atgcgcggtg gtgggaaatg gtgggattct gaagaagagt ggctgtggcc gtcaaataga tgaagcaaat tttgtcatgc gatgcaatct ccctcctttg tcaagtgaat acactaagga tgttggatcc aaaagtcagt tagtgacagc taatcccagc ataattcggc aaaggtttca gaaccttctg tggtccagaa agacatttgt ggacaacatg aaaatttata accacagtta catctacatg cctgcctttt ctatgaagac aggaacagag ccatctttga gggtttatta tacactgtca gatgttggtg ccaatcaaac agtgctgttt gccaacccca actttctgcg tagcattgga aagttctgga aaagtagagg aatccatgcc aagcgcctgt ccacaggact ttttctggtg agcgcagctc tgggtctctg tgaagaggtg gccatctatg gcttctggcc cttctctgtg aatatgcatg agcagcccat cagccaccac tactatgaca acgtcttacc cttttctggc ttccatgcca tgcccgagga atttctccaa ctctggtatc ttcataaaat cggtgcactg agaatgcagc tggacccatg tgaagatacc tcactccagc ccacttccta Protein function: Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3, gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid (PubMed:7937974, PubMed:8058740, PubMed:8195250, PubMed:8631981, PubMed:8706663, PubMed:18348864, PubMed:22885356). Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3 (PubMed:8631981). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed:8706663). Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells (PubMed:22885356). [The UniProt Consortium]