ST6GALNAC6 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or

Length: 1002 Sequence: atggcttgct cgaggccccc cagccagtgt gaacccacat ccctgccccc agggccacct gcaggacgcc gacacctacc cctcagcaga cgccggagag aaatgagtag caacaaagag cagcggtcag cagtgttcgt gatcctcttt gccctcatca ccatcctcat cctctacagc tccaacagtg ccaatgaggt cttccattac ggctccctgc ggggccgtag ccgccgacct gtcaacctca agaagtggag catcactgac ggctatgtcc ccattctcgg caacaagaca ctgccctctc ggtgccacca gtgtgtgatt gtcagcagct ccagccacct gctgggcacc aagctgggcc ctgagatcga gcgggctgag tgtacaatcc gcatgaatga tgcacccacc actggctact cagctgatgt gggcaacaag accacctacc gcgtcgtggc ccattccagt gtgttccgcg tgctgaggag gccccaggag tttgtcaacc ggacccctga aaccgtgttc atcttctggg ggcccccgag caagatgcag aagccccagg gcagcctcgt gcgtgtgatc cagcgagcgg gcctggtgtt ccccaacatg gaagcatatg ccgtctctcc cggccgcatg cggcaatttg acgacctctt ccggggtgag acgggcaagg acagggagaa gtctcattcg tggttgagca caggctggtt taccatggtg atcgcggtgg agttgtgtga ccacgtgcat gtctatggca tggtcccccc caactactgc agccagcggc cccgcctcca gcgcatgccc taccactact acgagcccaa ggggccggac gaatgtgtca cctacatcca gaatgagcac agtcgcaagg gcaaccacca ccgcttcatc accgagaaaa gggtcttctc atcgtgggcc cagctgtatg gcatcacctt ctcccacccc tcctggacct Protein function: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3- linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside). [The UniProt Consortium]