ST3GAL1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1023 Sequence: atggtgaccc tgcggaagag gaccctgaaa gtgctcacct tcctcgtgct cttcatcttc ctcacctcct tcttcctgaa ctactcccac accatggtgg ccaccacctg gttccccaag cagatggtcc tggagctctc cgagaacctg aagagactga tcaagcacag gccttgcacc tgcacccact gcatcgggca gcgcaagctc tcggcctggt tcgatgagag gttcaaccag accatgcagc cgctgctgac tgcccagaac gcgctcttgg aggacgacac ctaccgatgg tggctgaggc tccagcggga gaagaagccc aataacttga atgacaccat caaggagctg ttcagagtgg tgcctgggaa tgtggaccct atgctggaga agaggtcggt gggctgccgg cgctgcgccg ttgtgggcaa ctcgggcaac ctgagggagt cttcttatgg gcctgagata gacagtcacg actttgtcct caggatgaac aaggcgccca cggcagggtt tgaagctgat gttgggacca agaccaccca ccatctggtg taccctgaga gcttccggga gctgggagat aatgtcagca tgatcctggt gcccttcaag accatcgact tggagtgggt ggtgagcgcc atcaccacgg gcaccatttc ccacacctac atcccggttc ctgcaaagat cagagtgaaa caggataaga tcctgatcta ccacccagcc ttcatcaagt atgtctttga caactggctg caagggcacg ggcgataccc atctaccggc atcctctcgg tcatcttctc aatgcatgtc tgcgatgagg tggacttgta cggcttcggg gcagacagca aagggaactg gcaccactac tgggagaaca acccatccgc gggggctttt cgcaagacgg gggtgcacga tgcagacttt gagtctaacg tgacggccac cttggcctcc atcaataaaa tccggatctt caaggggaga Protein function: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl- neuraminic acid, Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:31784620, PubMed:8027041). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response. Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser. Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8027041). [The UniProt Consortium]