SPSB2 (Vector pUC, Accession No. BC002983)

Length: 792 Sequence: atgggccaga cagctctggc agggggcagc agcagcaccc ccacgccaca ggccctgtac cctgacctct cctgtcccga gggcttggaa gagctgctgt ctgcaccccc tcctgacctg ggggcccagc ggcgccacgg ttggaacccc aaagactgtt cagagaacat cgaggtcaag gaaggagggt tgtactttga gcggcggccc gtggcccaga gcactgatgg ggcccggggt aagaggggct attcaagggg cctgcacgcc tgggagatca gctggcccct agagcagagg ggcacgcatg ccgtggtggg cgtggccacg gccctcgccc cgctgcagac tgaccactac gcggcgctgc tgggcagcaa cagcgagtcg tggggctggg acatcgggcg ggggaagctg taccatcaga gcaaggggcc cggagccccc cagtatccag cgggaactca gggtgagcag ctggaggtgc cagagagact gctggtggtt ctggacatgg aggagggaac tctgggctac gctattgggg gcacctacct ggggccagca ttccgcggac tgaagggcag gaccctctat ccggcagtaa gcgctgtctg gggccagtgc caggtccgca tccgctacct gggcgaaagg agagcggagc cacactccct tctgcacctg agccgcctgt gtgtgcgcca caacctgggg gatacccggc tcggccaggt gtctgccctg cccttgcccc ctgccatgaa gcgctacctg ctctaccagt Protein function: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). [The UniProt Consortium]