SPRED2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1257 Sequence: atgaccgaag aaacacaccc agacgatgac agctatattg tgcgtgtcaa ggctgtggtt atgaccagag atgactccag cgggggatgg ttcccacagg aaggaggcgg gatcagtcgc gtcggggtct gtaaggtcat gcaccccgaa ggcaatggac gaagcggctt tctcatccat ggtgaacgac agaaagacaa actggtggta ttggaatgct atgtaagaaa ggacttggtc tacaccaaag ccaatccaac gtttcatcac tggaaggtcg ataataggaa gtttggactt actttccaaa gccctgctga tgcccgagcc tttgacaggg gagtaaggaa agcaatcgaa gaccttatag aaggttcaac aacgtcatct tccaccatcc ataatgaagc tgagcttggc gatgatgacg tttttacaac agctacagac agttcttcta attcctctca gaagagagag caacctactc ggacaatctc ctctcccaca tcctgtgagc accggaggat ttataccctg ggccacctcc acgactcata ccccacagac cactatcacc tcgatcagcc gatgccaagg ccctaccgcc aggtgagctt cccggacgac gacgaggaga tcgtgcgcat caacccccgg gagaagatct ggatgacggg gtacgaggat taccggcacg cacccgtcag gggcaagtac ccggacccct cggaggacgc ggactcctcc tacgtgcgct tcgccaaggg cgaggtcccc aagcatgact acaactaccc ctacgtggac tcctcagact ttggcctagg cgaggacccc aaaggccgcg ggggcagcgt gatcaagacg cagccctccc ggggcaagtc gcggcggcgg aaggaggacg gagagcgctc gcggtgcgtg tactgcaggg acatgttcaa ccacgaggag aaccgccggg gccactgcca ggacgcgccc gactccgtga gaacttgcat ccgccgggtg agctgcatgt ggtgcgcgga cagcatgctc tatcactgta tgtcggaccc cgagggagac tatacagacc cttgctcgtg cgatactagc gacgagaagt tttgcctccg gtggatggct cttattgcct tgtctttcct ggccccctgt atgtgctgtt acctgcccct tcgggcctgc taccactgcg gagtgatgtg caggtgctgt ggcgggaagc acaaagcggc Protein function: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells. [The UniProt Consortium]