SPOPL (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1179 Sequence: atgtctcggg aacccacccc acctctacct ggagatatgt ctactggtcc catagcagaa agctggtgtt acacacaggt taaagtagta aaattttcct atatgtggac cattaataac ttcagttttt gtcgagagga aatgggtgaa gtgttaaaaa gttcaacatt ttcatctggc ccaagtgaca aaatgaaatg gtgcctgagg gtaaacccaa agggattaga tgatgaaagt aaagactact tgtccttata tttgctttta gtcagctgcc ccaaaagtga agttcgagca aaattcaaat tttcccttct gaatgctaaa agggaagaaa caaaagcaat ggaaagccaa agagcatatc gatttgtgca agggaaggac tggggtttta aaaaattcat tagaagggac tttttgcttg atgaagctaa tggtctttta ccagatgaca agcttacatt attttgtgag gtgagtgtgg tccaagattc agtaaacata tcaggacata ctaatacaaa tactttgaag gtgcctgagt gtcgtctagc agaagattta ggtaatctct gggaaaacac aagatttaca gactgcagtt ttttcgtgag aggacaagaa tttaaagctc ataaatctgt gcttgcagct cgatctccag tttttaacgc catgtttgaa catgaaatgg aagaaagcaa aaagaatcga gtggaaataa atgatttaga ccctgaagtt tttaaagaaa tgatgagatt catttacaca gggagagcac caaaccttga caaaatggct gacaacttgt tggcagctgc agacaaatat gcactggaac ggctgaaggt catgtgcgaa gaagctttgt gtagtaacct ctcagtagag aatgttgcag atacccttgt ccttgcagat ttgcacagtg cagaacagtt gaaagcacaa gccatagact ttattaatag gtgcagtgta cttcgacaac ttgggtgtaa agatgggaaa aactggaaca gcaaccaagc aaccgacata atggaaacat cagggtggaa gtccatgatt cagtctcacc ctcatttagt agcagaagcc tttcgagcac tagcatctgc acagtgtcca cagtttggca ttccacgcaa acggctaaaa Protein function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complexes that contain SPOP. [The UniProt Consortium]