SPOP (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1125 Sequence: atgtcaaggg ttccaagtcc tccacctccg gcagaaatgt cgagtggccc cgtagctgag agttggtgct acacacagat caaggtagtg aaattctcct acatgtggac catcaataac tttagctttt gccgggagga aatgggtgaa gtcattaaaa gttctacatt ttcatcagga gcaaatgata aactgaaatg gtgtttgcga gtaaacccca aagggttaga tgaagaaagc aaagattacc tgtcacttta cctgttactg gtcagctgtc caaagagtga agttcgggca aaattcaaat tctccatcct gaatgccaag ggagaagaaa ccaaagctat ggagagtcaa cgggcatata ggtttgtgca aggcaaagac tggggattca agaaattcat ccgtagagat tttcttttgg atgaggccaa cgggcttctc cctgatgaca agcttaccct cttctgcgag gtgagtgttg tgcaagattc tgtcaacatt tctggccaga ataccatgaa catggtaaag gttcctgagt gccggctggc agatgagtta ggaggactgt gggagaattc ccggttcaca gactgctgct tgtgtgttgc cggccaggaa ttccaggctc acaaggctat cttagcagct cgttctccgg tttttagtgc catgtttgaa catgaaatgg aggagagcaa aaagaatcga gttgaaatca atgatgtgga gcctgaagtt tttaaggaaa tgatgtgctt catttacacg gggaaggctc caaacctcga caaaatggct gatgatttgc tggcagctgc tgacaagtat gccctggagc gcttaaaggt catgtgtgag gatgccctct gcagtaacct gtccgtggag aacgctgcag aaattctcat cctggccgac ctccacagtg cagatcagtt gaaaactcag gcagtggatt tcatcaacta tcatgcttcg gatgtcttgg agacctctgg gtggaagtca atggtggtgt cacatcccca cttggtggct gaggcatacc gctctctggc ttcagcacag tgcccttttc tgggaccccc acgcaaacgc ctgaagcaat Protein function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1, this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420). [The UniProt Consortium]