SPIB (Vector pUC, Accession No. BC007921)

Length: 789 Sequence: atgctcgccc tggaggctgc acagctcgac gggccacact tcagctgtct gtacccagat ggcgtcttct atgacctgga cagctgcaag cattccagct accctgattc agagggggct cctgactccc tgtgggactg gactgtggcc ccacctgtcc cagccacccc ctatgaagcc ttcgacccgg cagcagccgc ttttagccac ccccaggctg cccagctctg ctacgaaccc cccacctaca gccctgcagg gaacctcgaa ctggccccca gcctggaggc cccggggcct ggcctccccg cataccccac ggagaacttc gctagccaga ccctggttcc cccggcatat gccccgtacc ccagccctgt gctatcagag gaggaagact taccgttgga cagccctgcc ctggaggtct cggacagcga gtcggatgag gccctcgtgg ctggccccga ggggaaggga tccgaggcag ggactcgcaa gaagctgcgc ctgtaccagt tcctgctggg gctactgacg cgcggggaca tgcgtgagtg cgtgtggtgg gtggagccag gcgccggcgt cttccagttc tcctccaagc acaaggaact cctggcgcgc cgctggggcc agcagaaggg gaaccgcaag cgcatgacct accagaagct ggcgcgcgcc ctccgaaact acgccaagac cggcgagatc cgcaaggtca agcgcaagct cacctaccag ttcgacagcg cgctgctgcc tgcagtccgc Protein function: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. [The UniProt Consortium]