SPATA2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1563 Sequence: atggggaagc ccagttcaat ggatactaaa ttcaaggatg acttatttcg gaagtacgtg cagttccatg agagcaaagt ggataccacc accagcaggc agcggcctgg cagcgatgag tgcctgcggg tggcagcctc aaccctgctc agcctgcaca aggtggatcc cttttatcga ttccggctga tccagttcta tgaggtggtg gagagctcct tgcgctcgct cagctcctct agcctgcggg ctctgcacgg cgccttcagc atgctggaga cggtgggcat caacctcttc ctctacccgt ggaagaagga attcagaagc atcaagacct acacgggccc ttttgtttat tatgtcaagt cgacattact ggaagaggac atccgagcca tcctgagctg catgggctac acacctgagc tgggcactgc atacaagctc agagagctcg tggagaccct ccaggtgaag atggtctcct ttgagctctt tctggccaaa gtcgagtgtg agcagatgct agaaatccac tcacaagtga aggacaaggg ctactccgag ctggacattg tgagcgagcg caagagcagt gcagaggatg tgcgcggctg ctcggacgcc ctgcggcggc gggcagaggg ccgggagcac ctgacggcct ccatgtcacg agtggcactc cagaagtcgg ccagcgagcg ggcggccaag gactactaca agccccgcgt gaccaagccc tcgaggtcag tggatgccta tgacagctac tgggagagcc ggaagccacc cctgaaggcc tcattgagtc ttcggaagga gcctgtggca acggatgtgg gggacgacct caaggatgag atcatccgcc catccccttc gctgctgacc atggccagct ccccccacgg cagcccggat gtgcttccac ccgcctcccc cagcaacggc ccggccctgc tgcgcggtac ctacttctcc actcaggatg acgtggatct gtacacagac tctgaaccca gggccaccta ccgtcggcag gatgctctgc ggccggatgt gtggctgctc agaaacgatg cccactccct ctaccacaag cgctcgcccc ctgccaaaga gtccgccctc tccaagtgcc aaagctgcgg gctgtcctgc agctcctccc tctgccagcg ctgtgacagc ctgctcacct gtcctccagc ttccaagccc agcgccttcc ccagcaaggc ctcgactcat gacagcctgg cccacggggc atctctgcgg gagaagtacc caggccagac tcagggcctc gaccgcctcc cgcaccttca ctccaaatcc aagccctcca ccacgcccac ttcccgctgt ggcttctgca accgcccagg cgccaccaac acctgcaccc agtgttcaaa agtctcatgt gacgcctgcc tcagcgctta ccattatgac ccctgctaca aaaagagtga gctgcacaag ttcatgccca acaaccagct gaactacaag tccacccagc tctcccatct cgtgtacaga Protein function: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD. [The UniProt Consortium]