SPATA13 (Vector pUC, Accession No. BC109291)

Length: 1959 Sequence: ATGACTTCTG CCAGCCCTGA AGACCAGAAT GCTCCAGTGG GCTGCCCCAA AGGAGCCCGG AGAAGGCGCC CCATTTCCGT GATAGGTGGG GTCAGCTTGT ATGGGACCAA CCAGACGGAG GAACTGGACA ATCTTCTGAC CCAACCGGCT TCCAGGCCGC CCATGCCTGC TCACCAGGTG CCACCCTACA AGGCTGTGTC GGCCCGGTTC CGGCCCTTCA CATTCTCCCA GAGCACCCCC ATTGGGTTGG ACCGTGTGGG ACGCCGGCGG CAGATGAGAG CATCCAACGT TTCTTCAGAT GGAGGTACTG AGCCCTCTGC CTTAGTGGAT GACAACGGTA GTGAGGAGGA CTTCAGCTAT GAAGACCTCT GCCAGGCCAG CCCTCGGTAC CTGCAGCCCG GCGGGGAGCA GCTGGCCATC AATGAGCTGA TCAGTGATGG CAACGTGGTC TGCGCAGAAG CCCTGTGGGA CCATGTGACC ATGGATGACC AGGAACTGGG CTTCAAAGCC GGGGATGTCA TCCAGGTTCT GGAAGCCTCC AACAAGGACT GGTGGTGGGG CCGCAGTGAA GATAAGGAAG CCTGGTTCCC CGCGAGCTTC GTCAGATTGC GAGTGAATCA GGAAGAGCTG TCGGAAAACT CCAGCAGCAC CCCCAGTGAG GAGCAGGACG AGGAGGCCAG CCAGAGCCGC CACAGACACT GTGAGAACAA GCAGCAGATG CGGACCAACG TCATCCGGGA GATCATGGAC ACCGAGCGGG TGTACATCAA ACACCTCAGG GACATCTGTG AGGGCTATAT CCGACAGTGC CGCAAGCACA CAGGAATGTT CACCGTTGCG CAGCTAGCCA CTATTTTTGG AAACATTGAA GATATTTACA AATTCCAAAG AAAGTTTCTG AAAGACCTTG AGAAACAGTA CAACAAAGAG GAACCTCACT TAAGTGAAAT AGGATCTTGC TTTCTTCAAA ATCAAGAGGG CTTTGCCATC TATTCCGAGT ACTGCAACAA CCACCCGGGC GCCTGCCTGG AGCTCGCCAA CCTCATGAAG CAGGGCAAGT ACAGACATTT CTTTGAAGCC TGCCGCCTGC TGCAGCAGAT GATTGACATC GCCATCGACG GGTTCCTGCT CACACCAGTG CAGAAGATCT GCAAATACCC GCTGCAGCTG GCCGAGCTGC TCAAGTATAC CACACAGGAA CACGGTGATT ACAGCAACAT AAAGGCAGCA TATGAGGCCA TGAAGAATGT GGCCTGTCTG ATCAACGAGC GCAAGCGCAA GCTGGAGAGC ATCGACAAGA TAGCTCGCTG GCAGGTGTCT ATCGTGGGCT GGGAGGGACT GGATATCTTA GACCGAAGCT CAGAATTGAT TCATTCTGGG GAGCTGACCA AAATCACTAA GCAAGGCAAA AGCCAGCAGC GGACGTTCTT CCTGTTTGAC CACCAGCTGG TGTCCTGCAA GAAGGACCTG CTGCGCAGGG ACATGCTGTA CTACAAGGGC CGGCTGGACA TGGATGAGAT GGAGCTTGTG GACCTGGGGG ATGGGCGCGA CAAGGACTGC AACCTCAGCG TGAAAAATGC CTTCAAGCTC GTCAGTAGGA CCACAGACGA GGTTTATTTG TTTTGTGCCA AAAAACAAGA AGACAAGGCG AGGTGGCTGC AGGCCTGTGC AGATGAAAGG AGGCGGGTGC AAGAGGACAA GGAGATGGGA ATGGAAATTT CAGAAAACCA GAAGAAACTT GCCATGTTAA ATGCTCAAAA GGCAGGACAT GGAAAGTCAA AAGGCTACAA CAGGTGCCCT GTGGCCCCAC CGCACCAGGG CCTGCACCCC ATCCACCAGC GCCACATCAC TATGCCCACA AGCGTCCCCC AGCAGCAGGT CTTTGGCCTG GCGGAACCCA AGAGGAAGTC CTCGCTCTTC TGGCACACCT TCAACAGGCT CACCCCCTTC Protein function: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. [The UniProt Consortium]