SOX30 (Vector pUC, Accession No. BC033492)

Length: 2262 Sequence: atggagagag ccagacccga gccgccgcct cagccgcgcc cgttgcgtcc cgctccgccc ccgctgccgg tcgagggcac ctccttttgg gcagcagcca tggagccccc tccgtcgtct cccacactga gcgcggcagc cagtgcgacc ttggcctcgt cgtgcgggga ggcagtggcg tccggcttac agcccgcggt gcggcggctg ctgcaggtga agccagagca ggtgttgctg ctaccacagc ctcaggccca gaacgaggaa gccgctgcct cgtccgcgca ggcgcggctg ttgcagttca ggcccgacct gcggctcctg cagccgccga cagcgtcaga cggcgccacc tccaggcccg agttgcaccc ggtgcagccc ctggcgctgc atgtcaaggc caagaagcag aagctggggc ccagcctgga tcagtcagtg gggcctcgag gggccgtcga aaccggtcct agagcctcca gggtggtcaa gttggaaggc cccgggccgg ccctcggcta cttccgaggg gacgagaagg gcaagctgga ggcggaggag gtcatgagag actcgatgca aggcggggca ggcaaaagcc cggcagccat ccgagaaggt gtgatcaaaa cggaggaacc cgagagactc ctcgaggact gcaggctcgg cgcggagccc gcgtccaatg gcctggttca tggcagcgcg gaggtcatct tggccccaac gtccggtgcc tttgggccgc accagcaaga ccttaggatc cctttgacgc tccacacggt cccccctggg gcccggatcc agtttcaggg agctccgcct tcagagctga taagattgac caaggtcccc ctgacaccag tgcctactaa aatgcagtcc ctactggagc cttctgtaaa aattgaaacc aaagatgtcc cgctcaccgt gttgccctca gatgcaggca taccagatac tcccttcagt aaggacagaa atggtcatgt gaagcgaccc atgaacgcat ttatggtttg ggcaaggatc caccgaccag cactagccaa agctaaccca gcagccaaca atgcagaaat cagtgtccag cttgggttag agtggaacaa acttagtgaa gaacaaaaga aaccctatta cgatgaagca caaaagatta aggaaaagca cagagaggaa tttcctggtt gggtttatca gcctcgtcca gggaagcgaa aacgattccc tctaagtgtt tccaatgtat tttctggtac cacaaagaat atcatctcta caaatcctac aacagtttat ccttaccgct cacctacgta ctctgtggta attcccagcc tacagaatcc catcactcat ccagttggtg aaacctcacc tgctatccag ctgcccacac ctgcagtcca gagcccaagc cctgtcacac ttttccagcc cagcgtctcc agtgctgctc aggtggctgt ccaggatcca agtctacctg tctatccagc actcccaccc caacgcttta ctgggccttc ccaaacagac actcatcagc tgcattctga agccactcac actgtgaagc aacccactcc tgtctctcta gagagcgcca acaggatttc aagtagtgca agtactgccc atgccagatt tgcaacttcg accatccaac ctcctaggga gtattccagc gtttcccctt gtcccagaag tgctccaatc ccccaggctt ctcccattcc acacccacat gtctaccagc cccctcccct tggccatcca gccacactgt tcgggacacc accaagattc tcttttcatc acccttactt cctacccgga cctcactact tcccatcaag tacatgccct tacagtcggc ctccctttgg ctatggaaat tttccgagtt caatgccaga atgccttagt tattatgaag acaggtaccc aaaacatgag ggtatctttt caactttaaa tagagactat tcttttagag actactcaag tgaatgcaca cacagtgaaa attctcggag ttgtgagaac atgaatggaa cttcttacta taacagtcat agccacagtg gggaagaaaa cttaaaccct gtgcctcagc tggacattgg aaccttggag aatgtcttca cagccccgac atcaactcct tctagcatcc agcaagtcaa tgtcaccgac agtgatgagg aggaagaaga aaaagtgctc agggatttat Protein function: Acts as both a transcriptional activator and repressor (PubMed:10359848, PubMed:29739711). Binds to the DNA sequence 5'-ACAAT- 3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848). Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711). [The UniProt Consortium]