SNX27 (Vector pENTR223.1, Accession No. BC012184)

Length: 660 Sequence: atggacagta cgacagtgaa ttactttgcc ttatttgaag tgatcagtca ctcctttgta cgtaaattgg cacctaatga gtttcctcac aaactctaca ttcagaatta tacatcagct gtgccaggca cctgcttgac cattcgaaag tggcttttta caacagaaga agaaattctc ttaaatgaca atgaccttgc tgttacctac ttctttcatc aggcagtcga tgatgtgaag aaaggttaca tcaaagcaga agaaaagtcc tatcaattac agaagctata cgaacaaaga aaaatggtca tgtacctcaa catgctaagg acttgtgagg gctacaatga aatcatcttt ccccactgtg cctgtgactc caggaggaag gggcacgtta tcacagccat cagcatcacg cactttaaac tgcatgcctg cactgaagaa ggacagctgg agaaccaggt aattgcattt gaatgggatg agatgcagcg atgggacaca gatgaagaag ggatggcctt ctgtttcgaa tatgcacgag gagagaagaa gccccgatgg gttaaaatct tcacgccata tttcaattac atgcatgagt gcttcgagag ggtgttctgc gagctcaagt ggagaaaaga Protein function: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. [The UniProt Consortium]