SNX18 (Vector pUC, Accession No. BC060791)

Length: 1875 Sequence: ATGGCGCTGC GCGCCCGGGC GCTGTACGAC TTCAGGTCGG AGAACCCAGG AGAGATCTCG CTGCGAGAGC ACGAGGTGCT GAGCCTGTGC AGCGAGCAGG ACATCGAGGG CTGGCTCGAG GGGGTCAACA GCCGCGGCGA CCGCGGCCTC TTCCCGGCCT CCTATGTGCA GGTGATCCGC GCCCCCGAGC CTGGCCCGGC GGGAGACGGC GGCCCGGGCG CCCCGGCCCG CTACGCCAAT GTGCCCCCCG GGGGCTTCGA GCCCCTGCCC GTCGCGCCCC CCGCCTCCTT CAAGCCGCCG CCTGACGCCT TCCAGGCGCT GCTGCAGCCA CAGCAGGCGC CGCCTCCGAG CACCTTCCAG CCGCCCGGCG CGGGCTTCCC GTACGGCGGG GGCGCCCTGC AGCCGTCGCC TCAGCAGCTC TACGGCGGCT ACCAGGCCAG CCAAGGCAGC GATGATGACT GGGACGACGA GTGGGACGAC AGCTCCACGG TGGCGGACGA GCCGGGCGCT CTGGGCAGCG GAGCATACCC GGACCTCGAC GGCTCGTCTT CGGCGGGTGT GGGCGCAGCC GGCCGCTACC GCCTGTCCAC GCGCTCCGAC CTGTCCCTGG GCTCCCGCGG CGGCTCGGTC CCCCCGCAGC ACCACCCGTC GGGGCCCAAG AGCTCGGCCA CCGTGAGCCG CAACCTCAAT CGCTTCTCCA CCTTCGTCAA GTCCGGCGGG GAGGCCTTCG TGCTGGGGGA GGCGTCAGGC TTCGTGAAGG ACGGGGACAA GCTGTGCGTG GTGCTGGGGC CCTATGGCCC CGAGTGGCAG GAGAACCCCT ACCCGTTCCA GTGCACCATC GACGACCCCA CCAAGCAGAC CAAGTTCAAG GGCATGAAGA GCTACATCTC CTACAAGCTG GTGCCCACGC ACACGCAGGT GCCGGTGCAT CGGCGCTACA AGCACTTCGA CTGGCTGTAC GCGCGCCTGG CGGAGAAGTT CCCGGTCATC TCCGTGCCCC ACCTGCCCGA GAAGCAGGCC ACCGGCCGCT TCGAGGAGGA CTTCATCTCT AAGCGCAGGA AGGGCCTGAT CTGGTGGATG AACCACATGG CCAGCCACCC AGTGCTGGCG CAGTGCGACG TCTTCCAGCA CTTCCTGACG TGCCCCAGCA GCACCGACGA GAAAGCCTGG AAGCAGGGCA AGAGGAAGGC CGAGAAGGAC GAGATGGTGG GCGCCAACTT CTTCCTGACC CTTAGCACGC CCCCCGCCGC TGCCCTTGAC CTGCAGGAGG TGGAGAGCAA GATCGACGGC TTCAAGTGCT TCACCAAGAA GATGGACGAC AGCGCGCTGC AGCTCAACCA CACGGCCAAC GAGTTCGCGC GCAAGCAGGT GACCGGCTTC AAAAAGGAGT ATCAGAAGGT GGGCCAGTCC TTCCGCGGCC TCAGCCAGGC CTTTGAGCTG GACCAGCAGG CCTTCTCGGT GGGCCTGAAC CAGGCTATCG CCTTCACCGG AGATGCCTAT GACGCCATTG GCGAGCTCTT CGCGGAGCAG CCCAGGCAGG ACCTGGATCC CGTCATGGAC CTATTAGCGC TGTATCAGGG GCATCTGGCT AACTTCCCGG ACATCATCCA CGTTCAGAAA GGAGCTCTTA CCAAAGTCAA GGAGAGTAGG CGACACGTGG AGGAAGGGAA GATGGAGGTG CAGAAGGCTG ACGGCATTCA GGATCGCTGT AACACTATTT CTTTTGCCAC TTTGGCTGAA ATTCACCACT TCCATCAAAT TCGAGTGAGA GACTTTAAAT CACAGATGCA GCATTTCTTA CAACAACAAA TAATATTTTT CCAAAAAGTT ACCCAGAAGT TGGAAGAAGC TCTTCACAAA TATGATAGTG Protein function: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin- independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. [The UniProt Consortium]