SNF8 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 777 Sequence: atgcaccgcc gcggggtggg agctggcgcc atcgccaaga agaaacttgc agaggccaag tataaggagc gagggacggt cttggctgag gaccagctag cccagatgtc aaagcagttg gacatgttca agaccaacct ggaggaattt gccagcaaac acaagcagga gatccggaag aatcctgagt tccgtgtgca gttccaggac atgtgtgcaa ccattggcgt ggatccgctg gcctctggaa aaggattttg gtctgagatg ctgggcgtgg gggacttcta ttacgaacta ggtgtccaaa ttatcgaagt gtgcctggcg ctgaagcatc ggaatggagg tctgataact ttggaggaac tacatcaaca ggtgttgaag ggaaggggca agttcgccca ggatgtcagt caagatgacc tgatcagagc catcaagaaa ctaaaggcac ttggcactgg cttcggcatc atccctgtgg gcggcactta cctcattcag tctgttccag ctgagctcaa tatggatcac accgtggtgc tgcagctggc agagaagaat ggctacgtga ctgtcagtga gatcaaagcc agtcttaaat gggagaccga gcgagcgcgg caagtgctgg aacacctgct gaaggaaggg ttggcgtggc tggacttaca ggccccaggg gaggcccact actggctgcc agctctcttc actgacctct actcccagga gattacagct gaggaggcca gagaagccct Protein function: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). [The UniProt Consortium]