SMC1B (Vector pUC, Accession No. BC126208)

Length: 3486 Sequence: atggcccacc tggagctgct gcttgtggaa aatttcaagt cgtggcgggg ccgccaggtc attggcccct tccggaggtt cacctgcatc atcggcccca acggctctgg aaaatctaat gtaatggatg cacttagttt tgtaatggga gagaaaatag ctaatttaag agtgaaaaat attcaagaac tcattcatgg agcacatatt ggaaaaccta tttcttcttc tgcaagtgta aaaattatat atgtggagga aagtggcgaa gagaaaacat ttgcaaggat tatccgaggg ggatgctcag aatttcgctt taatgataat cttgtgagtc gttctgttta cattgcagag ttggaaaaga taggcataat agtcaaagca caaaattgtt tggtttttca gggaactgta gagtcaattt cagtgaagaa acccaaagaa aggacccagt tttttgagga aatcagcact tcaggagagc ttataggaga atatgaagaa aagaaaagaa agttacaaaa agccgaagag gatgcacagt ttaactttaa taagaaaaaa aatatagcgg cagagcgcag acaagcaaaa ttagagaagg aagaggcaga acgttaccag agtctccttg aagaactgaa aatgaacaag atacaactgc agctttttca actataccat aatgagaaaa agattcatct cctgaacacc aagttagagc atgtgaatag ggatttgagt gtcaaaagag agtctttgtc tcatcatgaa aacatagtta aagccaggaa aaaggaacat ggaatgctaa ctagacaact acaacaaaca gaaaaagaat taaaatcggt tgaaaccctt ttaaatcaga agaggcctca gtacattaaa gccaaagaaa acacttctca ccaccttaag aaattagatg tggctaagaa atcaataaag gacagcgaaa aacaatgttc taaacaggaa gatgatataa aagccctgga gacagagctg gctgatttag atgctgcatg gagaagtttt gaaaagcaga ttgaggaaga aattttacat aaaaagcgag acattgaact ggaagccagt cagctggatc gttataaaga acttaaggaa caagtaagaa agaaagtagc tacaatgact caacaactgg aaaaactgca gtgggaacag aagacagatg aagaaagact ggcatttgaa aagaggaggc atggagaagt tcagggaaat ctaaaacaaa taaaagaaca aatagaagat cataaaaaac gaatagagaa gttagaggag tatacaaaga catgcatgga ttgcttgaaa gagaaaaaac agcaagagga aaccctagtg gatgaaattg aaaaaacaaa atcaagaatg tctgaagtta atgaagaatt gaatcttatt agaagtgaat tgcagaatgc tgggattgat acccatgagg gaaaacgtca gcaaaagaga gcagaggttc tggaacacct taaaagactg tacccagatt ctgtgtttgg aagactattt gacctgtgtc atcctattca taagaaatac cagctggctg ttactaaggt ttttggccgg ttcatcactg ccattgttgt agcctctgaa aaggtagcaa aagattgtat tcgatttctg aaggaggaaa gagctgaacc tgagacattc ctcgctctag attaccttga tatcaagcca atcaatgaaa gactaaggga gcttaaaggc tgtaaaatgg tgattgatgt cataaagact cagtttcctc agctgaagaa agtgattcag tttgtgtgtg gaaatggtct tgtttgtgag actatggaag aagcaaggca tattgcactc agtggacctg aaagacagaa aacagtagct cttgatggaa cattattttt aaaatctgga gtgatctctg gagggtcaag tgacttaaaa tacaaggcta gatgctggga tgagaaagag ttaaagaatc taagagacag acgaagccag aaaatccaag agctaaaggg tttaatgaag acactccgca aagaaacaga tttgaaacaa atacagaccc tgatacaggg aactcaaaca cgactcaaat attcacaaaa tgaactagag atgattaaga agaagcacct tgttgctttt taccaggaac aatctcagtt acaaagtgaa ctactaaata ttgagtctca atgtattatg ttgagtgaag gaatcaagga acgacaacga agaattaaag aatttcaaga aaagatagat aaggtagaag acgatatctt ccaacacttc tgtgaagaaa ttggcgtgga aaatattcgt gaatttgaga acaaacatgt taaacggcaa caagaaattg atcaaaaaag attagaattt gaaaaacaaa aaactcggct taatgttcaa cttgagtata gtcgcagtca ccttaagaag aaactgaata agatcaacac attaaaagaa actatccaga aaggtagtga agatattgat cacctaaaga aggctgaaga aaactgtctg cagacagtga atgaactcat ggcaaagcag cagcaactta aggacatacg tgtcactcag aactccagtg ccgagaaagt tcaaactcaa attgaagagg aacggaagaa gtttctggct gttgataggg aagtggggaa attgcaaaaa gaagttgtaa gtattcaaac ttctctggaa cagaaacgat tagagaagca taacttgctg cttgattgca aagtgcaaga cattgagata atccttttgt cggggtcact ggatgacatc attgaagtgg agatgggaac tgaagcagaa agtacccagg caacaattga tatctatgaa aaagaagaag cctttgaaat agactacagc tctctaaaag aggatttgaa ggctctacag tctgatcaag aaatcgaggc ccaccttagg ctcttattgc agcaagtagc atcccaggaa gatatcttac tgaaaacagc agccccaaac ctacgagcac tggagaactt aaagactgtc agagacaagt ttcaagagtc cacagatgct tttgaggcca gcagaaagga agccagaatg tgtaggcaag agttcgagca agtgaaaaaa aggagatacg atcttttcac ccagtgtttt gagcatgtct caatctcaat tgatcaaatc tacaagaagc tctgcagaaa caacagcgcc caagtgtcaa gttacatcaa agagcaaact caagaccagt ttcagatgat agtcatctcc ctaaaagaag agttctattc cagagccgac gcgctgatcg gcatctatcc tgagtacgat gactgcatgt tcagccgagt tttgacccta gatctttctc agtatccaga cactgaaggc caagaaagca gcaagagaca cggagagtcc Protein function: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. [The UniProt Consortium]