SMARCD3 (Vector pUC, Accession No. BC002628)

Length: 1413 Sequence: atgactccag gtcttcagca cccacccacc gtggtacagc gccccgggat gccgtctgga gcccggatgc cccaccaggg ggcgcccatg ggccccccgg gctccccgta catgggcagc cccgccgtgc gacccggcct ggcccccgcg ggcatggagc ccgcccgcaa gcgagcagcg cccccgcccg ggcagagcca ggcacagagc cagggccagc cggtgcccac cgcccccgcg cggagccgca gtgccaagag gaggaagatg gctgacaaaa tcctccctca aaggattcgg gagctggtcc ccgagtccca ggcttacatg gacctcttgg catttgagag gaaactggat caaaccatca tgcggaagcg ggtggacatc caggaggctc tgaagaggcc catgaagcaa aagcggaagc tgcgactcta tatctccaac acttttaacc ctgcgaagcc tgatgctgag gattccgacg gcagcattgc ctcctgggag ctacgggtgg aggggaagct cctggatgat cccagcaaac agaagcggaa gttctcttct ttcttcaaga gtttggtcat cgagctggac aaagatcttt atggccctga caaccacctc gttgagtggc atcggacacc cacgacccag gagacggacg gcttccaggt gaaacggcct ggggacctga gtgtgcgctg cacgctgctc ctcatgctgg actaccagcc tccccagttc aaactggatc cccgcctagc ccggctgctg gggctgcaca cacagagccg ctcagccatt gtccaggccc tgtggcagta tgtgaagacc aacaggctgc aggactccca tgacaaggaa tacatcaatg gggacaagta tttccagcag atttttgatt gtccccggct gaagttttct gagattcccc agcgcctcac agccctgcta ttgccccctg acccaattgt catcaaccat gtcatcagcg tggacccttc agaccagaag aagacggcgt gctatgacat tgacgtggag gtggaggagc cattaaaggg gcagatgagc agcttcctcc tatccacggc caaccagcag gagatcagtg ctctggacag taagatccat gagacgattg agtccataaa ccagctcaag atccagaggg acttcatgct aagcttctcc agagacccca aaggctatgt ccaagacctg ctccgctccc agagccggga cctcaaggtg atgacagatg tagccggcaa ccctgaagag gagcgccggg ctgagttcta ccaccagccc tggtcccagg aggccgtcag tcgctacttc tactgcaaga tccagcagcg caggcaggag ctggagcagt cgctggttgt gcgcaacacc Protein function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [The UniProt Consortium]