SLC1A1 (Vector pUC, Accession No. BC033040)

Length: 1575 Sequence: atggggaaac cggcgaggaa aggatgcgag tggaagcgct tcctgaagaa taactgggtg ttgctgtcca ccgtggccgc ggtggtgcta ggcattacca caggagtctt ggttcgagaa cacagcaacc tctcaactct agagaaattc tactttgctt ttcctggaga aattctaatg cggatgctga aactcatcat tttgccatta attatatcca gcatgattac aggtgttgct gcactggatt ccaacgtatc cggaaaaatt ggtgtgcgcg ctgtcgtgta ttatttctgt accactctca ttgctgttat tctaggtatt gtgctggtgg tgagcatcaa gcctggtgtc acccagaaag tgggtgaaat tgcgaggaca ggcagcaccc ctgaagtcag tacggtggat gccatgttag atctcatcag gaatatgttc cctgagaatc ttgtccaggc ctgttttcag cagtacaaaa ctaagcgtga agaagtgaag cctcccagcg atccagagat gaacatgaca gaagagtcct tcacagctgt catgacaact gcaatttcca agaacaaaac aaaggaatac aaaattgttg gcatgtattc agatggcata aacgtcctgg gcttgattgt cttttgcctt gtctttggac ttgtcattgg aaaaatggga gaaaagggac aaattctggt ggatttcttc aatgctttga gtgatgcaac catgaaaatc gttcagatca tcatgtgtta tatgccacta ggtattttgt tcctgattgc tgggaagatc atagaagttg aagactggga aatattccgc aagctgggcc tttacatggc cacagtcctg actgggcttg caatccactc cattgtaatt ctcccgctga tatatttcat agtcgtacga aagaaccctt tccgatttgc catgggaatg gcccaggctc tcctgacagc tctcatgatc tcttccagtt cagcaacact gcctgtcacc ttccgctgtg ctgaagaaaa taaccaggtg gacaagagga tcactcgatt cgtgttaccc gttggtgcaa caatcaacat ggatgggact gcgctctatg aagcagtggc agcggtgttt attgcacagt tgaatgacct ggacttgggc attgggcaga tcatcaccat cagtatcacg gccacatctg ccagcatcgg agctgctggc gtgccccagg ctggcctggt gaccatggtg attgtgctga gtgccgtggg cctgcccgcc gaggatgtca ccctgatcat tgctgtcgac tggctcctgg accggttcag gaccatggtc aacgtccttg gtgatgcttt tgggacgggc attgtggaaa agctctccaa gaaggagctg gagcagatgg atgtttcatc tgaagtcaac attgtgaatc cctttgcctt ggaatccaca atccttgaca acgaagactc agacaccaag aagtcttatg tcaatggagg ctttgcagta gacaagtctg acaccatctc attcacccag acctcacagt Protein function: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport, this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5. [The UniProt Consortium]