SIX4 (Vector pUC, Accession No. BC098282)

Length: 2283 Sequence: ATGGAAAGCG CCTCGGAAGG GCAGGAGGCG CACCGAGAAG TGGCGGGGGG CGCGGCGGTA GGGCTGAGCC CCCCGGCTCC AGCCCCTTTT CCCCTGGAGC CGGGGGACGC CGCGACCGCT GCCGCCAGGG TGAGCGGAGA GGAAGGGGCA GTGGCGGCGG CGGCGGCCGG AGCGGCGGCG GATCAGGTAC AACTCCACTC GGAACTTCTG GGCAGGCACC ACCACGCCGC CGCCGCCGCC GCGCAGACCC CGCTGGCCTT CTCGCCCGAC CACGTCGCCT GCGTGTGCGA GGCACTGCAG CAGGGGGGCA ACCTGGACCG CCTGGCCCGG TTCCTGTGGT CCCTGCCCCA GAGCGACCTG CTACGTGGCA ACGAGAGCCT GCTGAAGGCG CGGGCGCTCG TGGCCTTCCA CCAGGGCATC TACCCCGAGC TCTACAGCAT CCTCGAGAGC CACAGCTTCG AGTCGGCCAA CCACCCGCTG CTGCAGCAGC TCTGGTACAA GGCGCGCTAC ACCGAGGCCG AGCGAGCCCG CGGCCGGCCG CTGGGAGCCG TAGACAAGTA CCGGCTGCGC AGGAAATTCC CCCTGCCCCG CACCATCTGG GACGGCGAGG AGACGGTGTA TTGTTTCAAG GAGAAGTCGC GCAACGCGCT CAAGGAGCTC TACAAGCAGA ATCGCTACCC TTCGCCCGCC GAGAAGCGGC ACCTGGCCAA GATCACCGGC CTCTCCCTCA CCCAGGTCAG CAACTGGTTC AAGAACCGCC GGCAGCGCGA CAGGAACCCC TCCGAGACCC AGTCCAAAAG TGAGTCAGAT GGCAACCCCA GCACTGAAGA TGAATCCAGC AAGGGACATG AGGATTTATC TCCTCACCCA CTCTCCAGTT CATCTGATGG CATCACCAAC CTCAGCCTTT CCAGTCATAT GGAGCCAGTA TATATGCAAC AAATTGGAAA TGCTAAGATA TCATTAAGCT CTTCTGGAGT TCTGTTGAAT GGAAGCTTGG TACCTGCAAG TACTTCACCT GTCTTCCTTA ATGGAAATTC TTTTATTCAG GGACCCAGTG GAGTTATCCT TAATGGATTA AATGTGGGAA ATACACAGGC AGTGGCATTG AACCCACCAA AAATGTCATC AAACATTGTG AGCAATGGTA TATCCATGAC TGACATACTG GGGTCTACTT CCCAGGACGT GAAGGAATTC AAAGTCCTCC AGAGTTCTGC TAACTCAGCA ACCACCACGT CCTACAGCCC CAGTGTCCCT GTCTCATTCC CAGGCCTGAT ACCCAGCACT GAGGTGAAAA GAGAAGGCAT TCAAACAGTG GCTTCCCAAG ATGGAGGGTC TGTAGTGACT TTTACTACAC CAGTGCAAAT TAACCAGTAT GGCATTGTCC AGATCCCCAA TTCCGGAGCA AACAGCCAGT TCCTTAATGG GAGCATTGGA TTCTCTCCAC TGCAGCTGCC CCCTGTGTCA GTGGCAGCTT CACAAGGTAA TATCTCAGTA AGCTCAAGCA CTTCAGATGG AAGCACATTT ACAAGTGAGT CTACCACAGT CCAGCAAGGA AAGGTTTTCT TGAGCTCTCT TGCTCCCAGT GCAGTGGTAT ACACGGTTCC TAATACAGGC CAGACTATAG GATCTGTGAA ACAGGAAGGC TTGGAAAGGA GCCTGGTATT TTCTCAGTTG ATGCCTGTCA ATCAGAATGC ACAAGTAAAT GCAAACCTGT CTTCTGAAAA CATCTCGGGG AGTGGCCTGC ATCCACTGGC CTCCTCATTA GTTAATGTAT CTCCAACTCA CAATTTTTCT CTCAGTCCCT CTACACTACT AAATCCCACT GAGCTAAACC GCGACATTGC CGATAGCCAA CCAATGTCTG CACCGGTGGC AAGCAAATCT ACTGTGACAT CTGTCAGCAA CACTAACTAT GCAACTCTTC AGAACTGCTC CCTTATTACT GGTCAAGACC TATTGTCAGT CCCTATGACT CAGGCTGCCC TTGGGGAAAT AGTTCCTACA GCTGAAGATC AGGTAGGTCA CCCCTCCCCA GCAGTACATC AGGATTTTGT CCAAGAACAT CGTTTGGTTC TGCAATCGGT AGCTAACATG AAAGAGAATT TCTTATCAAA TTCTGAGAGC AAAGCAACAA GTAGCTTAAT GATGCTGGAC TCTAAATCCA AGTATGTCTT AGATGGCATG GTTGATACTG TCTGTGAAGA CCTGGAAACA GACAAAAAAG AGCTTGCCAA GCTCCAGACT GTCCAGCTGG ATGAAGATAT GCAAGACTTA Protein function: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. [The UniProt Consortium]