SIX1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 855 Sequence: atgtcgatgc tgccgtcgtt tggctttacg caggagcaag tggcgtgcgt gtgcgaggtt ctgcagcaag gcggaaacct ggagcgcctg ggcaggttcc tgtggtcact gcccgcctgc gaccacctgc acaagaacga gagcgtactc aaggccaagg cggtggtcgc cttccaccgc ggcaacttcc gtgagctcta caagatcctg gagagccacc agttctcgcc tcacaaccac cccaaactgc agcaactgtg gctgaaggcg cattacgtgg aggccgagaa gctgtgcggc cgacccctgg gcgccgtggg caaatatcgg gtgcgccgaa aatttccact gccgcgcacc atctgggacg gcgaggagac cagctactgc ttcaaggaga agtcgagggg tgtcctgcgg gagtggtacg cgcacaatcc ctacccatcg ccgcgtgaga agcgggagct ggccgaggcc accggcctca ccaccaccca ggtcagcaac tggtttaaga accggaggca aagagaccgg gccgcggagg ccaaggaaag ggagaacacc gaaaacaata actcctcctc caacaagcag aaccaactct ctcctctgga agggggcaag ccgctcatgt ccagctcaga agaggaattc tcacctcccc aaagtccaga ccagaactcg gtccttctgc tgcagggcaa tatgggccac gccaggagct caaactattc tctcccgggc ttaacagcct cgcagcccag tcacggcctg cagacccacc agcatcagct ccaagactct ctgctcggcc ccctcacctc cagtctggtg gacttggggt Protein function: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation (PubMed:15141091). Mediates nuclear translocation of EYA1 and EYA2 (PubMed:19497856). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (PubMed:27923061, PubMed:23435380, PubMed:15141091, PubMed:19497856). Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2. Regulates the expression of CCNA1 (PubMed:15123840). Promotes brown adipocyte differentiation. [The UniProt Consortium]