SH3RF2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 663 Sequence: atgagaaaga gtaagtggtg gcagagagat ggatccctgc agagacccct ccagtccggg atccccactc tcgtggtagg ctccctcaga cgcagcccca ccatggtcct tcggcctcag cagttccaat tctaccagcc acaggggatc ccctcctccc cctcagccgt ggtggtggag atggggtcca agcctgccct cacgggggag cccgccctca cgtgcatcag caggggcagt gaggcccgga tccactccgc ggccagctcc ctcattatgg aagacaaaga aatccccatc aagagtgagc ctctgccaaa accgcccgca tctgccccac catccatcct ggtgaaacca gaaaactcaa gaaatggcat cgaaaagcaa gtcaaaaccg tgagatttca gaattacagc cctcctccca ccaaacatta cacctcccat cccacctccg gaaagcctga acagccagcc accctcaagg cgtcccagcc tgaagcagcg tccttgggcc cagagatgac cgtcctattt gcccaccgaa gtggctgcca ctccggacag cagacagacc tccggagaaa gtcagctctt gccaaggcca caaccctggt gtccactgcc tcaggcacgc agaccgtgtt tcccagcaaa Protein function: Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623). [The UniProt Consortium]